Ariel Feldstein, M.D.


3020 Children's Way
MC 5030
San Diego, CA 92123


Gastroenterology, Hepatology and Nutrition


Rady Children's Specialists of San Diego

Medical Group / IPA

Rady Children's Specialists

Medical School

Universidad de Buenos Aires


Mayo Clinic


Mayo Clinic

Board Certifications

Pediatric Gastroenterology, Pediatrics


Dr. Ariel Feldstein is chief of the Gastroenterology, Hepatology & Nutrition Division at Rady Children's Hospital-San Diego and a professor of pediatrics at UC San Diego School of Medicine.

After graduating from the Universidad de Buenos Aires Medical School and completing a postdoctoratal program in physiology at the Mayo Clinic, Dr. Feldstein went on to become the director of research for the Pediatric Institute at the Cleveland Clinic before moving to San Diego in 2011.

Dr. Feldstein oversees one of the largest pediatric gastroenterology divisions in the country, which is a top-ranked program by US News & World Report. He is a renowned pediatric hepatologist who pioneered the development of non-invasive blood tests to monitor liver damage. His research is supported by several grants from the National Institutes of Health, professional associations such as the American College of Gastroenterology and pharmaceutical industry leaders. He and his lab have made significant contributions to understanding and developing therapies for obesity-associated liver disease, now the most common form of chronic liver disease in children.

Dr. Feldstein has published over 120 peer-reviewed publications in various medical journals. He currently serves as the associate editor of Seminars for Liver Disease and has held editorial positions on other gastroenterology and hepatology journals. He is a member of the Society for Pediatric Research and numerous specialty societies and has held leadership roles in the American Gastroenterological Association and the American Association for the Study of Liver Diseases.

His goal is to use his research to develop safe and effective diagnostic and therapeutic strategies for patients with highly prevalent and potentially serious conditions.


Serum cytokeratin-18 fragment levels predict development of type 2 diabetes mellitus in adult patients with NAFLD
Nagpal, SJ, Lopez, R, Feldstein, AE, Alkhouri, N

Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation
Wree, A, Johnson, CD, Font-Burgada, J, Eguchi, A, Povero, D, Karin, M, Feldstein, AE

Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration
Eguchi, A, Mulya, A, Lazic, M, Radhakrishnan, D, Berk, MP, Povero, D, Gornicka, A, Feldstein, AE

Circulating soluble Fas and Fas ligand levels are elevated in children with nonalcoholic steatohepatitis
Alkhouri, N, Alisi, A, Okwu, V, Matloob, A, Ferrari, F, Crudele, A, De Vito, R, Lopez, R, Feldstein, AE, Nobili, V

Circulating microRNAs: emerging biomarkers of liver disease
Arrese, M, Eguchi, A, Feldstein, AE

Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis
Pizarro, M, Solis, N, Quintero, P, Barrera, F, Cabrera, D, Rojas-de Santiago, P, Arab, JP, Padilla, O, Roa, JC, Moshage, H, Wree, A, Inzaugarat, E, Feldstein, AE, Fardella, CE, Baudrand, R, Riquelme, A, Arrese, M

The evaluation of hepatic fibrosis scores in children with nonalcoholic Fatty liver disease
Mansoor, S, Yerian, L, Kohli, R, Xanthakos, S, Angulo, P, Ling, S, Lopez, R, Christine, C, Feldstein, AE, Alkhouri, N

Endoscopic treatment of pediatric post-transplant biliary complications is safe and effective
Dechene, A, Kodde, C, Kathemann, S, Treckmann, J, Lainka, E, Paul, A, Gerken, G, Feldstein, AE, Hoyer, PF, Canbay, A

Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease
Povero, D, Eguchi, A, Li, H, Johnson, CD, Papouchado, BG, Wree, A, Messer, K, Feldstein, AE

Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients
Wree, A, Schlattjan, M, Bechmann, LP, Claudel, T, Sowa, JP, Stojakovic, T, Scharnagl, H, Kofeler, H, Baba, HA, Gerken, G, Feldstein, AE, Trauner, M, Canbay, A

Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis
Navarro, LA, Wree, A, Povero, D, Berk, M, Ghosh, S, Papouchado, BG, Erzurum, SC, Feldstein, AE

Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease
Liu, H, Beier, J, Arteel, G, Ramsden, C, Feldstein, AE, McClain, CJ, Kirpich, IA

Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis
Lazic, M, Inzaugarat, E, Povero, D, Chen, I, Chen, M, Nalbandyan, M, Miller, YI, Chernavsky, AC, Feldstein, AE, Sears, DD

NLRP3 inflammasome activation is required for fibrosis development in NAFLD
Wree, A, McGeough, MD, Pena, CA, Schlattjan, M, Li, H, Inzaugarat, ME, Messer, K, Canbay, A, Hoffman, HM, Feldstein, AE

Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice
Lazic, M, Eguchi, A, Berk, MP, Povero, D, Papouchado, B, Mulya, A, Johnson, CD, Feldstein, AE

Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice
Aytekin, M, Tonelli, AR, Farver, CF, Feldstein, AE, Dweik, RA

Adipocyte cell death, fatty liver disease and associated metabolic disorders
Eguchi, A and Feldstein, AE

Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model
Thapaliya, S, Wree, A, Povero, D, Inzaugarat, ME, Berk, M, Dixon, L, Papouchado, BG, Feldstein, AE

Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures: a single-blinded pilot study
Navaneethan, U, Gutierrez, NG, Venkatesh, PG, Jegadeesan, R, Zhang, R, Jang, S, Sanaka, MR, Vargo, JJ, Parsi, MA, Feldstein, AE, Stevens, T

OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease
Alkhouri, N, Berk, M, Yerian, L, Lopez, R, Chung, YM, Zhang, R, McIntyre, TM, Feldstein, AE, Hazen, SL

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