Harold Hoffman, M.D.

Specialty

Allergy/Immunology

Organization

Rady Children's Specialists of San Diego

Medical Group / IPA

Rady Children's Specialists

Other Languages

Spanish

Medical School

University of Texas

Internship

University of South Carolina

Residency

University of South Carolina

Board Certifications

Allergy/Immunology

Gender

M

Publications

Brief Report: Severe Inflammation Following Vaccination Against Streptococcus pneumoniae in Patients With Cryopyrin-Associated Periodic Syndromes.
Walker UA, Hoffman HM, Williams R, Kuemmerle-Deschner J, Hawkins PN

The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis.
Rawson R, Anilkumar A, Newbury RO, Bafna V, Aquino M, Palmquist J, Hoffman HM, Mueller JL, Dohil R, Broide DH, Aceves SS

IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β.
Lee Y, Wakita D, Dagvadorj J, Shimada K, Chen S, Huang G, Lehman TJ, Fishbein MC, Hoffman HM, Crother TR, Arditi M

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.
de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.
Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK

Transplantation: Outcomes of prenatal immunosuppression.
Mak RH, Hoffman HM

A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1β-dependent macrophage immune response.
Lin AE, Beasley FC, Keller N, Hollands A, Urbano R, Troemel ER, Hoffman HM, Nizet V

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.
Toldo S, Mezzaroma E, McGeough MD, Peña CA, Marchetti C, Sonnino C, Van Tassell BW, Salloum FN, Voelkel NF, Hoffman HM, Abbate A

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.
Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G

The inflammasomes and autoinflammatory syndromes.
Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.
Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T

Possible cold autoinflammatory syndrome.
Lieberman P, Hoffman HM

cASCading specks.
Broderick L, Hoffman HM

IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.
Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS

NLRP3 inflammasome activation is required for fibrosis development in NAFLD.
Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE

The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media.
Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman SI

ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.
Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.
Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM

Methodological challenges in monitoring new treatments for rare diseases: lessons from the cryopyrin-associated periodic syndrome registry.
Tilson H, Primatesta P, Kim D, Rauer B, Hawkins PN, Hoffman HM, Kuemmerle-Deschner J, van der Poll T, Walker UA

Recurrent fevers and failure to thrive in an infant.
Scott DR, Chan S, Chang J, Broderick L, Hoffman HM

From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.
Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.
Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE

Long-term efficacy and safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: results of a 72-week open-label extension study.
Hoffman HM, Throne ML, Amar NJ, Cartwright RC, Kivitz AJ, Soo Y, Weinstein SP

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.
Miller M, Tam AB, Cho JY, Doherty TA, Pham A, Khorram N, Rosenthal P, Mueller JL, Hoffman HM, Suzukawa M, Niwa M, Broide DH

Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis.
Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.