Harold Hoffman, M.D.

Specialty

Allergy/Immunology

Organization

Rady Children's Specialists of San Diego

Medical Group / IPA

Rady Children's Specialists

Other Languages

Spanish

Medical School

University of Texas

Internship

University of South Carolina

Residency

University of South Carolina

Board Certifications

Allergy/Immunology

Gender

M

Bio

Dr. Hal M. Hoffman is a board-certified allergist/immunologist and chief of the Allergy, Immunology Division at Rady Children's Hospital-San Diego and UC San Diego.

Dr. Hoffman received his bachelor's in biology at Wesleyan University in Connecticut and his medical degree at the University of Texas Medical Branch in Galveston, Texas. He completed his internship, residency and chief residency in pediatrics at the Medical University of South Carolina in Charleston before coming to UCSD as a postdoctoral fellow in allergy and immunology in 1994. He is now a full professor of pediatrics and medicine at UC San Diego.

Dr. Hoffman has authored more than 70 original scientific publications, largely devoted to studying the NLRP3 inflammasome and innate immunity. He has participated in numerous national and international scientific boards, including serving as a member of the advisory board for the Arthritis National Research Foundation and as secretary for both the International Cytokine Society and the International Systemic Autoinflammatory Disease Society. He is also a member of the American Society of Clinical Investigators and the Society for Pediatric Research as well as a fellow of the American Academy of Allergy, Asthma and Immunology.

He has received numerous awards, including the American Lung Association of California Research Training Fellowship Award, American Lung Association of California Research Training Fellowship Award, Distinguished Fellows Asthma Education Scholarship Award, Merck Respiratory Young Investigator, AAAAI Education Research Trust Young Investigator Award, Arthritis Foundation-San Diego County Chapter Research Award and Sheldon Wolff Award for Translational Research. Most recently, Dr. Hoffman was honored with the International Society of Autoinflammatory Diseases Senior Investigator Award.

Publications

IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development.
Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS

Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm.
Wakita D, Kurashima Y, Crother TR, Noval Rivas M, Lee Y, Chen S, Fury W, Bai Y, Wagner S, Li D, Lehman T, Fishbein MC, Hoffman HM, Shah PK, Shimada K, Arditi M

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M

Brief Report: Severe Inflammation Following Vaccination Against Streptococcus pneumoniae in Patients With Cryopyrin-Associated Periodic Syndromes.
Walker UA, Hoffman HM, Williams R, Kuemmerle-Deschner J, Hawkins PN

The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis.
Rawson R, Anilkumar A, Newbury RO, Bafna V, Aquino M, Palmquist J, Hoffman HM, Mueller JL, Dohil R, Broide DH, Aceves SS

IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β.
Lee Y, Wakita D, Dagvadorj J, Shimada K, Chen S, Huang G, Lehman TJ, Fishbein MC, Hoffman HM, Crother TR, Arditi M

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.
de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.
Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK

Transplantation: Outcomes of prenatal immunosuppression.
Mak RH, Hoffman HM

A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1β-dependent macrophage immune response.
Lin AE, Beasley FC, Keller N, Hollands A, Urbano R, Troemel ER, Hoffman HM, Nizet V

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.
Toldo S, Mezzaroma E, McGeough MD, Peña CA, Marchetti C, Sonnino C, Van Tassell BW, Salloum FN, Voelkel NF, Hoffman HM, Abbate A

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.
Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G

The inflammasomes and autoinflammatory syndromes.
Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.
Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T

Possible cold autoinflammatory syndrome.
Lieberman P, Hoffman HM

cASCading specks.
Broderick L, Hoffman HM

IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.
Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS

NLRP3 inflammasome activation is required for fibrosis development in NAFLD.
Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE

The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media.
Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman SI

ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.
Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.
Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM

Methodological challenges in monitoring new treatments for rare diseases: lessons from the cryopyrin-associated periodic syndrome registry.
Tilson H, Primatesta P, Kim D, Rauer B, Hawkins PN, Hoffman HM, Kuemmerle-Deschner J, van der Poll T, Walker UA

Recurrent fevers and failure to thrive in an infant.
Scott DR, Chan S, Chang J, Broderick L, Hoffman HM

From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.
Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.
Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

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