Lori Broderick, M.D., Ph.D.

Locations

3020 Children's Way
MC 5114
San Diego, CA 92123

Specialty

Allergy/Immunology

Organization

Rady Children's Specialists of San Diego

Medical Group / IPA

Rady Children's Specialists

Medical School

State University of New York at Buffalo (Medicine)

Internship

University of California - San Diego

Fellowship

University of California - San Diego

Board Certifications

Allergy/Immunology, Pediatrics

Gender

F

Bio

Dr. Lori Broderick is a board-certified allergist/immunologist at Rady Children's Hospital-San Diego and an assistant professor of pediatrics at UC San Diego, with specific interests in disorders of pediatric immunity.

Dr. Broderick earned her undergraduate degree from Syracuse University in New York, graduating summa cum laude. She then received her doctorate in tumor immunology and her medical degree at the University of Buffalo in New York. She completed her pediatric residency at UC San Diego, where she developed an interest in patients with primary immunodeficiencies and autoinflammatory syndromes, also known as periodic fever disorders. She then completed a fellowship in allergy and immunology at UC San Diego, receiving extensive training to diagnose and manage primary immunodeficiency, allergic disorders and autoinflammation.

At UC San Diego, Dr. Broderick performs translational research to study the genetics and inflammatory etiology of autoinflammatory disorders, specifically periodic fever, aphthosus stomatitis, pharyngitis and adenitis (PFAPA) syndrome, as well as the identification of novel immunodeficiencies.

Dr. Broderick is the recipient of a number of distinctions and research awards from organizations including the American Academy of Pediatrics, the Thrasher Research Fund, The Hartwell Foundation, the A.P. Giannini Foundation and the Arthritis National Research Foundation. She is an active member of the American Academy of Allergy, Asthma, and Immunology; the International Society of Systemic Auto-Inflammatory Diseases; the Clinical Immunology Society and the San Diego Allergy Society.

Publications

The role of the inflammasome in patients with autoinflammatory diseases.
Hoffman HM, Broderick L

Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency.
Broderick L

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.
Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G

The inflammasomes and autoinflammatory syndromes.
Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.
Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T

cASCading specks.
Broderick L, Hoffman HM

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.
Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM

Recurrent fevers and failure to thrive in an infant.
Scott DR, Chan S, Chang J, Broderick L, Hoffman HM

From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.
Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE

Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis.
Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF

Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models.
McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD

Prolonged urticaria and fever in a toddler.
Broderick L, Tremoulet AH, Burns JC, Hoffman HM

Biologic modulators in allergic and autoinflammatory diseases.
Broderick L, Tourangeau LM, Kavanaugh A, Wasserman SI

Recurrent fever syndromes in patients after recovery from Kawasaki syndrome.
Broderick L, Tremoulet AH, Burns JC, Bastian JF, Hoffman HM

Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells.
Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ Jr, Yokota SJ, Bankert RB

Membrane-associated TGF-beta1 inhibits human memory T cell signaling in malignant and nonmalignant inflammatory microenvironments.
Broderick L, Bankert RB

Memory T cells in human tumor and chronic inflammatory microenvironments: sleeping beauties re-awakened by a cytokine kiss.
Broderick L, Bankert RB

Human nasal polyp microenvironment maintained in viable and functional states as xenografts in SCID mice.
Bernstein JM, Broderick L, Parsons RR, Bankert RB

IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells.
Broderick L, Brooks SP, Takita H, Baer AN, Bernstein JM, Bankert RB

Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells.
Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ Jr, Bankert RB

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.