Ralph Holmes, M.D.


Plastic Surgery, Cleft Palate and Craniofacial


3020 Children's Way
MC 5031
San Diego, CA 92123


Plastic Surgery, Cleft Palate and Craniofacial


Rady Children's Specialists of San Diego

Medical Group / IPA

Rady Children's Specialists

Medical School

Boston University School of Medicine


Santa Clara Valley Hospital


University of Texas, Yale University School of Medicine

Board Certifications

Plastic Surgery




Dr. Ralph Holmes is a board-certified plastic surgeon and a pediatric plastic surgery specialist at Rady Children's Hospital-San Diego. He is also a voluntary professor of plastic surgery at UC San Diego.

A native of San Diego, Dr. Holmes received his medical degree from Boston University School of Medicine and his otolaryngology training at the Yale-New Haven Medical Center. His interest in reconstructive surgery led him to complete plastic surgery training at the University of Texas Southwestern Medical Center in Dallas.

After serving as a professor and chief of the Plastic Surgery Division at UC San Diego from 1995 to 1999, Dr. Holmes relocated to Rady Children's to focus on his primary interests of craniofacial surgery, cleft lip and palate surgery, ear reconstruction and surgery for skin conditions.

A founder of the Birthmark Clinic and the Vascular Lesion Clinic at Rady Children's, Dr. Holmes enjoys collaborating closely with the Pediatric Dermatology Division. He also has a personal interest in reconstruction of the outer ear and was the first to bring to Rady Children's modern techniques of creating new ears from rib cartilage for children with microtia. He also enjoys collaborating with the Genetics, Otolaryngology and Audiology services, and working with the Cleft Palate Team.

Dr. Holmes was previously chief of Rady Children's Pediatric Surgery Division and remains committed to excellence in surgical care for all children with pediatric and craniofacial conditions.

He has published more than 70 journal papers and 10 book chapters, and given 160 scientific presentations.


Review of bone substitutes.
Pryor LS, Gage E, Langevin CJ, Herrera F, Breithaupt AD, Gordon CR, Afifi AM, Zins JE, Meltzer H, Gosman A, Cohen SR, Holmes R

ArteFill: a long-lasting injectable wrinkle filler material--summary of the U.S. Food and Drug Administration trials and a progress report on 4- to 5-year outcomes.
Cohen SR, Berner CF, Busso M, Gleason MC, Hamilton D, Holmes RE, Romano JJ, Rullan PP, Thaler MP, Ubogy Z, Vecchione TR

Histomorphometric and fluorescence microscopic evaluation of interfacial bone healing around 3 different dental implants before and after radiation therapy.
Weinlaender M, Beumer J 3rd, Kenney EB, Lekovic V, Holmes R, Moy PK, Plenk H Jr

Clinical experience with a new fast-resorbing polymer for bone stabilization in craniofacial surgery.
Cohen SR, Mittermiller PA, Holmes RE, Broder KW

Reconstruction of complex orbitocranial deformities using bioresorbable mesh, sterilized orbital models, and in situ contouring.
Punja KG, Kikkawa DO, Morrison VL, Pornpanich K, Holmes RE, Cohen SR

Identifying potential regulators of infantile hemangioma progression through large-scale expression analysis: a possible role for the immune system and indoleamine 2,3 dioxygenase (IDO) during involution.
Ritter MR, Moreno SK, Dorrell MI, Rubens J, Ney J, Friedlander DF, Bergman J, Cunningham BB, Eichenfield L, Reinisch J, Cohen S, Veccione T, Holmes R, Friedlander SF, Friedlander M

Artecoll: a long-lasting injectable wrinkle filler material: Report of a controlled, randomized, multicenter clinical trial of 251 subjects.
Cohen SR, Holmes RE

Fronto-orbital and cranial osteotomies with resorbable fixation using an endoscopic approach.
Cohen SR, Holmes RE, Ozgur BM, Meltzer HS, Levy ML

MacroPore resorbable devices in craniofacial surgery.
Holmes RE, Cohen SR, Cornwall GB, Thomas KA, Kleinhenz KK, Beckett MZ

Craniofacial reconstruction with a fast resorbing polymer: a 6- to 12-month clinical follow-up review.
Cohen SR, Holmes RE, Meltzer HS, Levy ML, Beckett MZ

Distraction osteogenesis of the porcine mandible: histomorphometric evaluation of bone.
Glowacki J, Shusterman EM, Troulis M, Holmes R, Perrott D, Kaban LB

Immediate cranial vault reconstruction with bioresorbable plates following endoscopically assisted sagittal synostectomy.
Cohen SR, Holmes RE, Meltzer HS, Nakaji P

Surgical strategies in the treatment of complex obstructive sleep apnoea in children.
Cohen SR, Holmes RE, Machado L, Magit A

Midface distraction following Le Fort III and monobloc osteotomies: problems and solutions.
Gosain AK, Santoro TD, Havlik RJ, Cohen SR, Holmes RE

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.