Rady Children's Hospital San Diego

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Dr. Gabriel G. Haddad Receives Prestigious Government Grant to Lead Hypoxia Tolerance Research Study

Dr. Gabriel G. Haddad, Physician-in-Chief, Rady Children’s Hospital-San Diego, and Chair, Department of Pediatrics, UC San Diego, has been awarded a $10 million program project grant from the National Heart, Lung, and Blood Institute (a division of the National Institutes of Health).

A world-renowned physician-scientist in pediatric pulmonary medicine, Dr. Haddad will lead a collaborative team of investigators from UCSD and the Sanford-Burnham Medical Research Institute to study the impact of low oxygen on cells and tissue in the heart, lung and brain. Understanding the molecular, cellular and genetic mechanisms that contribute to low oxygen tolerance or susceptibility will have a major impact on treatments of central nervous system and cardiorespiratory diseases and events, including stroke, heart attack, obstructive sleep apnea and pulmonary hypertension.

The overall aims of this project are:
 
  • To study the adaptive mechanisms to hypoxia in cardiovascular and respiratory systems at both cellular and molecular levels;
  • To study the fundamental genetic mechanisms of tolerance in a Drosophila model;
  • To modulate/manipulate molecular mechanisms in mammalian cells/tissues/animals to render them hypoxia-tolerant after learning from a tolerant organism, e.g., the fly; and
  • To identify molecular signatures of hypoxia tolerance and susceptibility that may be predictive clinically.
The investigative team includes:
 
Gabriel G. Haddad, M.D., Chair Pediatrics, UCSD (PI of the PPG)
 
Jason Yuan, M.D., Ph.D., Professor, Pulmonary, Critical Care, and Sleep Medicine, University of Illinois at Chicago

Rolf Bodmer, Ph.D., Professor and Director, Development and Aging Program, Sanford-Burnham Institute for Medical Research

Andrew McCulloch, Ph.D., Professor, Department of Bioengineering, UCSD
 
Giovanni Paternostro, M.D., Ph.D., Assistant Professor, The Sanford-Burnham Institute for Medical Research
 
Frank Powell, Ph.D., Professor of Medicine, Physiology Division, UCSD and Director, University of California White Mountain Research Station
 
 
 
Image -- Photo -- Haddad Research Page

Dr. Gabriel Haddad is a world-renowned physician-researcher in the field of pulmonary medicine.