Research and Clinical Trials
The Division’s research programs range from basic science projects on the effect of disordered respiration, hypoxia and hypercapnia on cell function and fate in vital organs, to cutting-edge basic and clinical research on cystic fibrosis. Faculty scholars provide research training and mentorship to future investigators.
Among our current research projects, Gabriel G. Haddad, M.D., Physician-in-Chief at Rady Children’s Hospital-San Diego and Chair of the Department of Pediatrics at the University of California, San Diego, is leading a collaborative team of investigators from UC San Diego and the Sanford-Burnham Medical Research Institute to study the impact of low oxygen on cells and tissue in the heart, lung and brain.
Understanding the molecular, cellular and genetic mechanisms that contribute to low oxygen tolerance or susceptibility will have a major impact on treatments of central nervous system and cardiorespiratory diseases and events, including stroke, heart attack, obstructive sleep apnea and pulmonary hypertension. This research is funded by a $10 million project grant from the National Heart, Lung, and Blood Institute.
Recently, Dr. Haddad and another research team decoded the genetic basis of chronic mountain sickness (CMS) or Monge’s disease. The study provides important information that validates the genetic basis of adaptation to high altitudes and provides potential targets for CMS treatment. Read more.
For detailed information on the research activities of our members, visit the UC San Diego Department of Pediatrics website.
Dr. Gabriel G. Haddad is a world-renowned physician-scientist in pulmonary medicine.