A widely accepted method of treating reduced blood flow to the heart – called percutaneous coronary intervention (PCI) — is a relatively common procedure in adult patients but not a generally accepted option for infants or toddlers with acute coronary syndrome. That could be changing, however, based on research conducted by the cardiology team at Rady Children’s Hospital-San Diego.
In a new report published in the August issue of Catheterization and Cardiovascular Interventions, the official journal of The Society for Cardiovascular Angiography and Interventions (SCAI), Rady Children’s researchers found coronary stent implantation to be a feasible and safe palliative option for children fifteen months and younger.
Studies have shown that in adults with reduced blood flow to the heart—known as acute coronary syndrome (ACS)—stent implantation significantly reduces mortality. While ACS is less common in children there are congenital and acquired heart disease that may compromise coronary circulation in the pediatric population. Due to increased risk of coronary interventions and difficulty of cardiac catheterization techniques in pediatric patients, PCI is not a recommended treatment strategy in this age group.
A research team led by Dr. András Bratincsák from Rady Children’s conducted a retrospective review of seven children who had PCI between June 2006 and June 2010. Of those included in the study all were under 18 years of age and four were 15 months or younger. PCI techniques included balloon coronary angioplasty and coronary stent implantation. Researchers analyzed patient data that included underlying diagnosis, comorbidites, catheterization technique, and outcomes.
In all seven cases, successful stent placement in the proximal portion of the left or right coronary arteries with excellent revascularization was achieved. The average diameter of the heart arteries was 0.65 mm prior to the intervention. Balloon angioplasty did not completely resolve the stenosis and bare metal stents were then implanted to a mean internal diameter of 2.5 mm. The team determined that the average intervention-free period was 434 days after stent implantation. Restenosis and thrombosis did not occur in cases where the implanted stent diameter was greater than 2.5 mm and patients received dual anti-platelet therapy.
"We provide evidence that stent implantation is a relatively safe option for pediatric patients with coronary stenosis, including those under the age of 15 months,” said Dr. Bratincsák. “PCI offers a viable strategy for bridging infants and toddlers with blocked arteries or poor ventricular function to surgical revascularization or transplantation when they are at an older age.”
About Rady Children’s Hospital-San Diego:
Rady Children’s Hospital-San Diego, the largest children’s hospital in California, is a 442-bed pediatric care facility providing the largest source of comprehensive pediatric medical services in San Diego, Southern Riverside and Imperial counties. Rady Children’s is the only hospital in the San Diego area dedicated exclusively to pediatric healthcare and is the region’s only designated pediatric trauma center. On October 10, 2010, Rady Children’s opened the Acute Care Pavilion, a LEED-Certified (green) building that is home to the incredible Peckham Center for Cancer and Blood Disorders, the state-of-the-art Warren Family Surgical Center, and a Neonatal Intensive Care Unit that cares for our community’s most fragile newborns. In May 2011, U.S. News & World Report ranked Rady Children’s among the best children’s hospitals in the nation in all ten pediatric specialties the magazine surveyed. For more information, visit www.rchsd.org and find us on Facebook, Twitter and YouTube.