, Gastroenterology, Hepatology and Nutrition
3020 Children's Way
San Diego, CA 92123
Gastroenterology, Hepatology and Nutrition
Rady Children's Specialists of San Diego
Universidad de Buenos Aires
Pediatric Gastroenterology, Pediatrics
Dr. Ariel Feldstein is chief of the Gastroenterology, Hepatology & Nutrition Division at Rady Children's Hospital-San Diego and a professor of pediatrics at UC San Diego School of Medicine.
After graduating from the Universidad de Buenos Aires Medical School and completing a postdoctoratal program in physiology at the Mayo Clinic, Dr. Feldstein went on to become the director of research for the Pediatric Institute at the Cleveland Clinic before moving to San Diego in 2011.
Dr. Feldstein oversees one of the largest pediatric gastroenterology divisions in the country, which is a top-ranked program by U.S. News & World Report. He is a renowned pediatric hepatologist who pioneered the development of non-invasive blood tests to monitor liver damage. His research is supported by several grants from the National Institutes of Health, professional associations such as the American College of Gastroenterology and pharmaceutical industry leaders. He and his lab have made significant contributions to understanding and developing therapies for obesity-associated liver disease, now the most common form of chronic liver disease in children.
Dr. Feldstein has published over 120 peer-reviewed publications in various medical journals. He currently serves as the associate editor of Seminars for Liver Disease and has held editorial positions on other gastroenterology and hepatology journals. He is a member of the Society for Pediatric Research and numerous specialty societies and has held leadership roles in the American Gastroenterological Association and the American Association for the Study of Liver Diseases.
His goal is to use his research to develop safe and effective diagnostic and therapeutic strategies for patients with highly prevalent and potentially serious conditions.
A low n-6 to n-3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth.
TricÃ² D, Galderisi A, Van Name MA, Caprio S, Samuels S, Li Z, Galuppo BT, Savoye M, Mari A, Feldstein AE, Santoro N
Cell-to-Cell Communications in Alcohol-Associated Liver Disease.
Osna NA, Eguchi A, Feldstein AE, Tsukamoto H, Dagur RS, Ganesan M, New-Aaron M, Arumugam MK, Chava S, Ribeiro M, Szabo G, Mueller S, Wang S, Chen C, Weinman SA, Kharbanda KK
Protein and miRNA profile of circulating extracellular vesicles in patients with primary sclerosing cholangitis.
Povero D, Tameda M, Eguchi A, Ren W, Kim J, Myers R, Goodman ZD, Harrison SA, Sanyal AJ, Bosch J, Ohno-Machado L, Feldstein AE
NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH.
Calcagno DM, Chu A, Gaul S, Taghdiri N, Toomu A, Leszczynska A, Kaufmann B, Papouchado B, Wree A, Geisler L, Hoffman HM, Feldstein AE, King KR
Dual role of neutrophils in modulating liver injury and fibrosis during development and resolution of diet-induced murine steatohepatitis.
Kim AD, Kim SE, Leszczynska A, Kaufmann B, Reca A, Kim DJ, Feldstein AE
Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner.
Holtmann TM, Inzaugarat ME, Knorr J, Geisler L, Schulz M, Bieghs V, Frissen M, Feldstein AE, Tacke F, Trautwein C, Wree A
Pyroptosis in Steatohepatitis and Liver Diseases.
Knorr J, Wree A, Feldstein AE
Feeding mice a diet high in oxidized linoleic acid metabolites does not alter liver oxylipin concentrations.
Liang N, Hennebelle M, Gaul S, Johnson CD, Zhang Z, Kirpich IA, McClain CJ, Feldstein AE, Ramsden CE, Taha AY
Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity.
Arrese M, Arab JP, Barrera F, Kaufmann B, Valenti L, Feldstein AE
Novel Mechanisms for Resolution of Liver Inflammation: Therapeutic Implications.
Kaufmann B, Reca A, Kim AD, Feldstein AE
Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH.
Daemen S, Gainullina A, Kalugotla G, He L, Chan MM, Beals JW, Liss KH, Klein S, Feldstein AE, Finck BN, Artyomov MN, Schilling JD
Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis.
Koh EH, Yoon JE, Ko MS, Leem J, Yun JY, Hong CH, Cho YK, Lee SE, Jang JE, Baek JY, Yoo HJ, Kim SJ, Sung CO, Lim JS, Jeong WI, Back SH, Baek IJ, Torres S, Solsona-Vilarrasa E, Conde de la Rosa L, Garcia-Ruiz C, Feldstein AE, Fernandez-Checa JC, Lee KU
Characterization and Proteome of Circulating Extracellular Vesicles as Potential Biomarkers for NASH.
Povero D, Yamashita H, Ren W, Subramanian MG, Myers RP, Eguchi A, Simonetto DA, Goodman ZD, Harrison SA, Sanyal AJ, Bosch J, Feldstein AE
Mechanisms of nonalcoholic fatty liver disease and implications for surgery.
Kaufmann B, Reca A, Wang B, Friess H, Feldstein AE, Hartmann D
Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis.
Gaul S, Leszczynska A, Alegre F, Kaufmann B, Johnson CD, Adams LA, Wree A, Damm G, Seehofer D, Calvente CJ, Povero D, Kisseleva T, Eguchi A, McGeough MD, Hoffman HM, Pelegrin P, Laufs U, Feldstein AE
The Power of Single-Cell Analysis for the Study of Liver Pathobiology.
Chu AL, Schilling JD, King KR, Feldstein AE
A Low Ï‰-6 to Ï‰-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.
Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N
Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1Î² and IL-17 upregulation in alcoholic hepatitis mice.
Eguchi A, Yan R, Pan SQ, Wu R, Kim J, Chen Y, Ansong C, Smith RD, Tempaku M, Ohno-Machado L, Takei Y, Feldstein AE, Tsukamoto H
The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis.
Knorr J, Wree A, Tacke F, Feldstein AE
ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model.
Schuster-Gaul S, Geisler LJ, McGeough MD, Johnson CD, Zagorska A, Li L, Wree A, Barry V, Mikaelian I, Jih LJ, Papouchado BG, Budas G, Hoffman HM, Feldstein AE
Designing Clinical Trials in Pediatric Nonalcoholic Steatohepatitis: Tips for Patient Selection and Appropriate Endpoints.
Alkhouri N, Kohli R, Feldstein AE
Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/chronic fatigue syndrome.
Eguchi A, Fukuda S, Kuratsune H, Nojima J, Nakatomi Y, Watanabe Y, Feldstein AE
MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury.
Jimenez Calvente C, Del Pilar H, Tameda M, Johnson CD, Feldstein AE
Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223.
Calvente CJ, Tameda M, Johnson CD, Del Pilar H, Lin YC, Adronikou N, De Mollerat Du Jeu X, Llorente C, Boyer J, Feldstein AE
NAFLD in children: new genes, new diagnostic modalities and new drugs.
Nobili V, Alisi A, Valenti L, Miele L, Feldstein AE, Alkhouri N
See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.
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