, Gastroenterology, Hepatology and Nutrition
3020 Children's Way
San Diego, CA 92123
Gastroenterology, Hepatology and Nutrition
Rady Children's Specialists of San Diego
Rady Children's Specialists
Universidad de Buenos Aires
Pediatric Gastroenterology, Pediatrics
Dr. Ariel Feldstein is chief of the Gastroenterology, Hepatology & Nutrition Division at Rady Children's Hospital-San Diego and a professor of pediatrics at UC San Diego School of Medicine.
After graduating from the Universidad de Buenos Aires Medical School and completing a postdoctoratal program in physiology at the Mayo Clinic, Dr. Feldstein went on to become the director of research for the Pediatric Institute at the Cleveland Clinic before moving to San Diego in 2011.
Dr. Feldstein oversees one of the largest pediatric gastroenterology divisions in the country, which is a top-ranked program by U.S. News & World Report. He is a renowned pediatric hepatologist who pioneered the development of non-invasive blood tests to monitor liver damage. His research is supported by several grants from the National Institutes of Health, professional associations such as the American College of Gastroenterology and pharmaceutical industry leaders. He and his lab have made significant contributions to understanding and developing therapies for obesity-associated liver disease, now the most common form of chronic liver disease in children.
Dr. Feldstein has published over 120 peer-reviewed publications in various medical journals. He currently serves as the associate editor of Seminars for Liver Disease and has held editorial positions on other gastroenterology and hepatology journals. He is a member of the Society for Pediatric Research and numerous specialty societies and has held leadership roles in the American Gastroenterological Association and the American Association for the Study of Liver Diseases.
His goal is to use his research to develop safe and effective diagnostic and therapeutic strategies for patients with highly prevalent and potentially serious conditions.
TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies.
McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, PeÃ±a CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM
Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice.
Warner DR, Liu H, Miller ME, Ramsden CE, Gao B, Feldstein AE, Schuster S, McClain CJ, Kirpich IA
NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL- 17 and TNF.
Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, PeÃ±a CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE
Tmbim 1, a novel anti-inflammatory approach for NASH treatment.
Wree A, Inzaugarat ME, Feldstein AE
Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis.
Cabrera D, Wree A, Povero D, SolÃs N, Hernandez A, Pizarro M, Moshage H, Torres J, Feldstein AE, Cabello-Verrugio C, Brandan E, Barrera F, Arab JP, Arrese M
Inflammasomes in Liver Fibrosis.
Alegre F, Pelegrin P, Feldstein AE
NASH: Novel therapeutic strategies targeting ASK1 in NASH.
Schuster S, Feldstein AE
Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?
TricÃ² D, Di Sessa A, Caprio S, Chalasani N, Liu W, Liang T, Graf J, Herzog RI, Johnson CD, Umano GR, Feldstein AE, Santoro N
Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis.
Cannito S, Morello E, Bocca C, Foglia B, Benetti E, Novo E, Chiazza F, Rogazzo M, Fantozzi R, Povero D, Sutti S, Bugianesi E, Feldstein AE, Albano E, Collino M, Parola M
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
Mridha AR, Wree A, Robertson AAB, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC
Treating nonalcoholic steatohepatitis in children: Not a cinch task.
Alkhouri N, Feldstein AE
Update on lipid species and paediatric nonalcoholic fatty liver disease.
Mann JP, Feldstein AE, Nobili V
Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress.
Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, Quehenberger O, Sears DD, Feldstein AE
Fatty liver in adolescents: Mechanisms, clinical features and therapy.
Nobili V, Feldstein AE
Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood.
Eguchi A, Lazaro RG, Wang J, Kim J, Povero D, Willliams B, Ho SB, StÃ¤rkel P, Schnabl B, Ohno-Machado L, Tsukamoto H, Feldstein AE
Hepatocyte mitochondrial DNA released in microparticles and toll-like receptor 9 activation: A link between lipotoxicity and inflammation during nonalcoholic steatohepatitis.
Inzaugarat ME, Wree A, Feldstein AE
Noninvasive diagnosis of nonalcoholic fatty liver disease: Are we there yet?
Alkhouri N, Feldstein AE
Similarities and differences between pediatric and adult nonalcoholic fatty liver disease.
Crespo M, Lappe S, Feldstein AE, Alkhouri N
Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice.
Smathers RL, Chiang DJ, McMullen MR, Feldstein AE, Roychowdhury S, Nagy LE
Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis.
Povero D, Feldstein AE
Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis.
Wree A, Mehal WZ, Feldstein AE
Innate Immunity and Inflammation in NAFLD/NASH.
Arrese M, Cabrera D, Kalergis AM, Feldstein AE
Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-Î³.
Povero D, Panera N, Eguchi A, Johnson CD, Papouchado BG, de Araujo Horcel L, Pinatel EM, Alisi A, Nobili V, Feldstein AE
Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis.
Eguchi A, De Mollerat Du Jeu X, Johnson CD, Nektaria A, Feldstein AE
Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study.
Goffredo M, Caprio S, Feldstein AE, D'Adamo E, Shaw MM, Pierpont B, Savoye M, Zhao H, Bale AE, Santoro N
See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.
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