Gabriel Haddad, M.D.


3020 Children's Way
MC 5109
San Diego, CA 92123


Pulmonology/Respiratory Medicine


Rady Children's Specialists of San Diego

Medical Group / IPA


Board Certifications

Pulmonology/Respiratory Medicine




Dr. Gabriel G. Haddad is physician-in-chief and chief scientific officer at Rady Children's Hospital-San Diego and chairman of the Department of Pediatrics at UC San Diego School of Medicine. A leading specialist in pediatric respiratory medicine, he is also an accomplished physician-scientist.

Receiving his medical education and initial medical training at the American University of Beirut in Lebanon, Dr. Haddad went on to complete additional training at the University of Texas in Houston, followed by a fellowship at Columbia University in New York, where he joined the faculty in 1978. A decade later, he accepted an appointment at Yale to direct the Respiratory Medicine Section and serve as chief of clinical service in respiratory medicine. Shortly thereafter, he became a professor of cellular & molecular physiology. In 2002, he was appointed chairman of the Department of Pediatrics at Albert Einstein College of Medicine in New York and also pediatrician-in-chief at The Children's Hospital at Montefiore Hospital.

Dr. Haddad is passionate about developing better care through research. In recent years, his research has focused on the basis for cell and tissue injury at the molecular level when tissues and organs are deprived of nutrients and oxygen.

Dr. Haddad has published more than 350 articles and manuscripts, written more than 100 chapters, and authored numerous medical texts including the landmark "Basic Mechanisms of Pediatric Respiratory Disease." He sits on numerous national committees, including those of the National Heart, Lung and Blood Institute and March of Dimes, and is a member of 18 distinguished medical societies, many in a leadership role.

Additionally, Dr. Haddad has held numerous editorial appointments, is a reviewer for 29 respected medical journals and is the recipient of numerous awards and honors, including election into the Association of American Physicians. He has been invited to speak at more than 160 national and international conferences and is also a member of the St. Jude Children's Research Hospital Board of Governors.

Dr. Haddad is married and the father of three children, a daughter and two sons.


Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders.
Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG

Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia.
Stobdan T, Zhou D, Williams AT, Cabrales P, Haddad GG

Exploring miRNA-mRNA regulatory network in cardiac pathology in Na<sup>+</sup>/H<sup>+</sup> exchanger isoform 1 transgenic mice.
Xue J, Zhou D, Poulsen O, Hartley I, Imamura T, Xie EX, Haddad GG

Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome.
Tripathi A, Melnik AV, Xue J, Poulsen O, Meehan MJ, Humphrey G, Jiang L, Ackermann G, McDonald D, Zhou D, Knight R, Dorrestein PC, Haddad GG

Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness.
Yao H, Zhao H, Wang J, Haddad GG

Mitochondrial dysfunction in iPSC-derived neurons of subjects with chronic mountain sickness.
Zhao H, Perkins G, Yao H, Callacondo D, Appenzeller O, Ellisman M, La Spada AR, Haddad GG

Down-regulation of Inwardly Rectifying K<sup>+</sup> Currents in Astrocytes Derived from Patients with Monge's Disease.
Wu W, Yao H, Zhao HW, Wang J, Haddad GG

New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude.
Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad GG

High-altitude adaptation in humans: from genomics to integrative physiology.
Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad GG

Transcriptomic analysis identifies a role of PI3K-Akt signalling in the responses of skeletal muscle to acute hypoxia in vivo.
Gan Z, Powell FL, Zambon AC, Buchholz KS, Fu Z, Ocorr K, Bodmer R, Moya EA, Stowe JC, Haddad GG, McCulloch AD

Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis, Partially via Trimethylamine-Oxide.
Xue J, Zhou D, Poulsen O, Imamura T, Hsiao YH, Smith TH, Malhotra A, Dorrestein P, Knight R, Haddad GG

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.
Azad P, Zhao HW, Cabrales PJ, Ronen R, Zhou D, Poulsen O, Appenzeller O, Hsiao YH, Bafna V, Haddad GG

The Na<sup>+</sup>/HCO<sub>3</sub><sup>-</sup> co-transporter is protective during ischemia in astrocytes.
Yao H, Azad P, Zhao HW, Wang J, Poulsen O, Freitas BC, Muotri AR, Haddad GG

Intermittent hypoxia induces murine macrophage foam cell formation by IKK-β-dependent NF-κB pathway activation.
Imamura T, Poulsen O, Haddad GG

Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits.
Aggarwal DD, Rashkovetsky E, Michalak P, Cohen I, Ronin Y, Zhou D, Haddad GG, Korol AB

Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations.
Jha AR, Zhou D, Brown CD, Kreitman M, Haddad GG, White KP

Cardiac responses to hypoxia and reoxygenation in Drosophila.
Zarndt R, Piloto S, Powell FL, Haddad GG, Bodmer R, Ocorr K

Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.
Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG

Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism.
Manchenkov T, Pasillas MP, Haddad GG, Imam FB

Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.
Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX

A Drosophila ABC transporter regulates lifespan.
Huang H, Lu-Bo Y, Haddad GG

High-throughput cell death assays.
Pamenter ME, Haddad GG

The genetic basis of chronic mountain sickness.
Ronen R, Zhou D, Bafna V, Haddad GG

Hematopoietic stem cells: potential new applications for translational medicine.
Felfly H, Haddad GG

Wnt pathway activation increases hypoxia tolerance during development.
Gersten M, Zhou D, Azad P, Haddad GG, Subramaniam S

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.

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