Kelan Tantisira, M.D., M.P.H.

Bio

Dr. Tantisira is chief of the Division of Respiratory Medicine at Rady Children's Hospital-San Diego and a professor of pediatrics at UC San Diego School of Medicine.

Dr. Tantisira has over 32 years of experience practicing medicine and comes to Rady Children's from the Brigham and Women's Hospital. His primary research focus is on the factors influencing asthma susceptibility, severity, prognosis and treatment response, with particular interests in asthma pharmacogenomics, translational genomics, and personalized, prognostic medicine. He has directed seminal studies in respiratory epidemiology, genomics and pharmacogenomics, as well as the fetal genomic origins of lung disease.

After graduating from the University of Pittsburgh School of Medicine, Dr. Tantisira completed his residency in internal medicine and pediatrics at the LA County/University of Southern California Medical Center. He then completed fellowships in pediatric pulmonology and in adult pulmonary and critical care medicine at Massachusetts General Hospital, as well as a research fellowship in respiratory epidemiology at the Brigham and Women's Hospital. He is board certified in pulmonary disease.

Publications

Circulating MicroRNAs and Treatment Response in Childhood Asthma
Li J, Panganiban R, Kho AT, McGeachie MJ, Farnam L, Chase RP, Weiss ST, Lu Q, Tantisira KG

Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD
Kachroo P, Morrow JD, Kho AT, Vyhlidal CA, Silverman EK, Weiss ST, Tantisira KG, DeMeo DL

Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid
Kang MG, Lee HS, Tantisira KG, Park HW

Real-Life Patterns of Exacerbations While on Inhaled Corticosteroids and Long-Acting Beta Agonists for Asthma over 15 Years
McGeachie MJ, Wang AL, Lutz SM, Sordillo JE, Weiss ST, Tantisira KG, Iribarren C, Lu MX, Wu AC

COMPSRA: a COMprehensive Platform for Small RNA-Seq data Analysis
Li J, Kho AT, Chase RP, Pantano L, Farnam L, Amr SS, Tantisira KG

Genome-wide interaction study reveals age-dependent determinants of responsiveness to inhaled corticosteroids in individuals with asthma
Dahlin A, Sordillo JE, McGeachie M, Kelly RS, Tantisira KG, Lutz SM, Lasky-Su J, Wu AC

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Merid SK, Novoloaca A, Sharp GC, Kpers LK, Kho AT, Roy R, Gao L, Annesi- Maesano I, Jain P, Plusquin M, Kogevinas M, Allard C, Vehmeijer FO, Kazmi N, Salas LA, Rezwan FI, Zhang H, Sebert S, Czamara D, Rifas-Shiman SL, Melton PE, Lawlor DA, Pershagen G, Breton CV, Huen K, Baiz N, Gagliardi L, Nawrot TS, Corpeleijn E, Perron P, Duijts L, Nohr EA, Bustamante M, Ewart SL, Karmaus W, Zhao S, Page CM, Herceg Z, Jarvelin MR, Lahti J, Baccarelli AA, Anderson D, Kachroo P, Relton CL, Bergstrom A, Eskenazi B, Soomro MH, Vineis P, Snieder H, Bouchard L, Jaddoe VW, Sorensen TIA, Vrijheid M, Arshad SH, Holloway JW, Haberg SE, Magnus P, Dwyer T, Binder EB, DeMeo DL, Vonk JM, Newnham J, Tantisira KG, Kull I, Wiemels JL, Heude B, Sunyer J, Nystad W, Munthe-Kaas MC, Raikkonen K, Oken E, Huang RC, Weiss ST, Anto JM, Bousquet J, Kumar A, Soderhall C, Almqvist C, Cardenas A, Gruzieva O, Xu CJ, Reese SE, Kere J, Brodin P, Solomon O, Wielscher M, Holland N, Ghantous A, Hivert MF, Felix JF, Koppelman GH, London SJ, Melen E

Plasmalogens Mediate the Effect of Age on Bronchodilator Response in Individuals With Asthma
Sordillo JE, Lutz SM, Kelly RS, McGeachie MJ, Dahlin A, Tantisira K, Clish C, Lasky-Su J, Wu AC

Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy
McGeachie MJ, Sordillo JE, Dahlin A, Wang AL, Lutz SM, Tantisira KG, Panganiban R, Lu Q, Sajuthi S, Urbanek C, Kelly R, Saef B, Eng C, Oh SS, Kho AT, Croteau-Chonka DC, Weiss ST, Raby BA, Mak ACY, Rodriguez-Santana JR, Burchard EG, Seibold MA, Wu AC

Mechanical forces induce an asthma gene signature in healthy airway epithelial cells
Kılı? A, Ameli A, Park JA, Kho AT, Tantisira K, Santolini M, Cheng F, Mitchel JA, McGill M, O'Sullivan MJ, De Marzio M, Sharma A, Randell SH, Drazen JM, Fredberg JJ, Weiss ST

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation
King C, McKenna A, Farzan N, Vijverberg SJ, van der Schee MP, Maitland-van der Zee AH, Arianto L, Bisgaard H, B?nnelykke K, Berce V, Potočnik U, Repnik K, Carleton B, Daley D, Chew FT, Chiang WC, Sio YY, Cloutier MM, Den Dekker HT, Duijts L, de Jongste JC, Dijk FN, Koppelman GH, Flores C, Hernandez-Pacheco N, Pino-Yanes M, Mukhopadhyay S, Basu K, Bignell L, Tantisira KG, Turner S, Verhamme KM, Francis B, Pirmohamed M, Sinha I, Hawcutt DB

DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics
Wang AL, Gruzieva O, Qiu W, Kebede Merid S, Celed?n JC, Raby BA, S?derh?ll C, DeMeo DL, Weiss ST, Mel?n E, Tantisira KG

Identification of a key gene module associated with glucocorticoid- induced derangement in bone mineral density in patients with asthma
Lee SY, Won HK, Kim BK, Kim SH, Chang YS, Cho SH, Kelly HW, Tantisira KG, Park HW

A nuclease-polymerase chain reaction enables amplification of probes used for capture-based DNA target enrichment
Leong KW, Yu F, Adalsteinsson VA, Reed S, Gydush G, Ladas I, Li J, Tantisira KG, Makrigiorgos GM

Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions
Kelly RS, Sordillo JE, Lutz SM, Avila L, Soto-Quiros M, Celed?n JC, McGeachie MJ, Dahlin A, Tantisira K, Huang M, Clish CB, Weiss ST, Lasky-Su J, Wu AC

DNA methylation is associated with improvement in lung function on inhaled corticosteroids in pediatric asthmatics
Wang AL, Qiu W, DeMeo DL, Raby BA, Weiss ST, Tantisira KG

Gene expression changes in lymphoblastoid cell lines and primary B cells by dexamethasone
Park HW, Dahlin A, Qiu W, Tantisira KG

New Statistical Methods for Constructing Robust Differential Correlation Networks to characterize the interactions among microRNAs
Yu D, Zhang Z, Glass K, Su J, DeMeo DL, Tantisira K, Weiss ST, Qiu W

Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes
Choi J, Tantisira KG, Duan QL

Remission of persistent childhood asthma: Early predictors of adult out�comes
Wang AL, Datta S, Weiss ST, Tantisira KG