Praveen Raju, M.D., Ph.D

Bio

Praveen Raju, MD, PhD is the Nathan Gordon Chair in Neuro-Oncology and Director of Pediatric Neuro-Oncology at Rady Children’s Hospital-San Diego and the University of California, San Diego (UCSD) School of Medicine.

Dr. Raju completed MD and PhD training in Molecular Biology and Genetics with a focus on Developmental Neurobiology at the University of Pennsylvania School of Medicine. He then completed his Pediatrics residency training at Babies and Children’s Hospital/Columbia-Presbyterian Medical Center and his Pediatric Neurology fellowship at Boston Children's Hospital/Harvard Medical School followed by an NIH-funded Pediatric Scientist Development Program (PSDP) research fellowship in advanced mouse genetics and developmental neurobiology at Memorial Sloan Kettering Cancer Center.

Following his clinical and research training, Dr. Raju established his initial independent faculty position at Weill Cornell Medicine in 2010 where he was the Caryl and Israel Englander Clinical Scholar in Children’s Health and provided clinical care to children on the pediatric neurology and neuro-oncology service at Memorial Sloan Kettering Cancer Center. In 2020, Dr. Raju was recruited to the Icahn School of Medicine at Mount Sinai where he established and co-directed the Children’s Brain and Spinal Tumor Center at Kravis Children’s Hospital. In addition, he also established and directed the Pediatric Neurology Residency Program and also served as Associate Director of the MD-PhD Program at Mount Sinai until his recruitment to Rady Children’s Hospital and UCSD in early 2024.

In addition to his clinical and educational duties, Dr. Raju runs a translational mouse genetics-based research lab focused on pediatric brain tumors with a recent focus on nanomedicine-based drug delivery approaches to bypass the blood-brain barrier. He has published or co-authored several research articles related to pediatric neuro-oncology including in prestigious journals such as Nature Materials, Cell Reports, JCI, Cancer Cell, Science Advances, Cell, and Immunity and has given over 45 invited lectures internationally on this topic. His research work has been funded by multiple NIH R01 grants and the US Department of Defense as well as foundation grants including from Hyundai Hope on Wheels Foundation, Alex’s Lemonade Stand Foundation, St. Baldrick’s Foundation, Unravel Pediatric Cancer, Hartwell Foundation, American Brain Tumor Association (ABTA), Mithil Prasad Foundation, STARR Consortium, Emerson Collective, and Cookies for Kids’ Cancer among others.

Publications

Childhood cancer mutagenesis caused by transposase-derived PGBD5.
Yamada M, Keller RR, Gutierrez RL, Cameron D, Suzuki H, Sanghrajka R, Vaynshteyn J, Gerwin J, Maura F, Hooper W, Shah M, Robine N, Demarest P, Bayin NS, Zapater LJ, Reed C, Hébert S, Masilionis I, Chaligne R, Socci ND, Taylor MD, Kleinman CL, Joyner AL, Raju GP, Kentsis A

A road map for the treatment of pediatric diffuse midline glioma.
Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, Becher O, Cartaxo R, Castro MG, Chung C, Clausen M, Dang D, Doherty R, Duchatel R, Dun M, Filbin M, Franson A, Galban S, Garcia Moure M, Garton H, Gowda P, Marques JG, Hawkins C, Heath A, Hulleman E, Ji S, Jones C, Kilburn L, Kline C, Koldobskiy MA, Lim D, Lowenstein PR, Lu QR, Lum J, Mack S, Magge S, Marini B, Martin D, Marupudi N, Messinger D, Mody R, Morgan M, Mota M, Muraszko K, Mueller S, Natarajan SK, Nazarian J, Niculcea M, Nuechterlein N, Okada H, Opipari V, Pai MP, Pal S, Peterson E, Phoenix T, Prensner JR, Pun M, Raju GP, Reitman ZJ, Resnick A, Rogawski D, Saratsis A, Sbergio SG, Souweidane M, Stafford JM, Tzaridis T, Venkataraman S, Vittorio O, Wadden J, Wahl D, Wechsler-Reya RJ, Yadav VN, Zhang X, Zhang Q, Venneti S

Case report: A novel biallelic FTO variant causing multisystem anomalies with severe epilepsy, widening the spectrum of FTO syndrome.
Mayman N, Wei J, Cai S, Soman R, Raynes H, La Vega-Talbott M, He C, Naidich T, Raju GP, Kathiresu Nageshwaran S

P-selectin-targeted nanocarriers induce active crossing of the blood-brain barrier via caveolin-1-dependent transcytosis.
Tylawsky DE, Kiguchi H, Vaynshteyn J, Gerwin J, Shah J, Islam T, Boyer JA, Boué DR, Snuderl M, Greenblatt MB, Shamay Y, Raju GP, Heller DA

A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis.
Dhar S, Gadd S, Patel P, Vaynshteyn J, Raju GP, Hashizume R, Brat DJ, Becher OJ

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.
Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Mark MT, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, Offer K, Nakajima M, Williams C, Nogués L, Pelissier Vatter FA, Hashimoto A, Davies AE, Freitas D, Kenific CM, Ararso Y, Buehring W, Lauritzen P, Ogitani Y, Sugiura K, Takahashi N, Alečković M, Bailey KA, Jolissant JS, Wang H, Harris A, Schaeffer LM, García-Santos G, Posner Z, Balachandran VP, Khakoo Y, Raju GP, Scherz A, Sagi I, Scherz-Shouval R, Yarden Y, Oren M, Malladi M, Petriccione M, De Braganca KC, Donzelli M, Fischer C, Vitolano S, Wright GP, Ganshaw L, Marrano M, Ahmed A, DeStefano J, Danzer E, Roehrl MHA, Lacayo NJ, Vincent TC, Weiser MR, Brady MS, Meyers PA, Wexler LH, Ambati SR, Chou AJ, Slotkin EK, Modak S, Roberts SS, Basu EM, Diolaiti D, Krantz BA, Cardoso F, Simpson AL, Berger M, Rudin CM, Simeone DM, Jain M, Ghajar CM, Batra SK, Stanger BZ, Bui J, Brown KA, Rajasekhar VK, Healey JH, de Sousa M, Kramer K, Sheth S, Baisch J, Pascual V, Heaton TE, La Quaglia MP, Pisapia DJ, Schwartz R, Zhang H, Liu Y, Shukla A, Blavier L, DeClerck YA, LaBarge M, Bissell MJ, Caffrey TC, Grandgenett PM, Hollingsworth MA, Bromberg J, Costa-Silva B, Peinado H, Kang Y, Garcia BA, O'Reilly EM, Kelsen D, Trippett TM, Jones DR, Matei IR, Jarnagin WR, Lyden D

Rapid reversal of uremic neuropathy following renal transplantation in an adolescent.
Ho DT, Rodig NM, Kim HB, Lidov HG, Shapiro FD, Raju GP, Kang PB

MASTR: a technique for mosaic mutant analysis with spatial and temporal control of recombination using conditional floxed alleles in mice.
Lao Z, Raju GP, Bai CB, Joyner AL

Hedgehog inhibition as an anti-cancer strategy.
Raju GP, Pham D

Arsenic: a potentially useful poison for Hedgehog-driven cancers.
Raju GP

Germinal matrix hemorrhage in Zellweger syndrome.
Takenouchi T, Raju GP

B cell depletion therapy for new-onset opsoclonus-myoclonus.
Pranzatelli MR, Tate ED, Swan JA, Travelstead AL, Colliver JA, Verhulst SJ, Crosley CJ, Graf WD, Joseph SA, Kelfer HM, Raju GP

Postvaricella acute transverse myelitis in a previously vaccinated child.
LaRovere KL, Raju GP, Gorman MP

A case of congenital glycogen storage disease type IV with a novel GBE1 mutation.
Raju GP, Li HC, Bali DS, Chen YT, Urion DK, Lidov HG, Kang PB

Oxcarbazepine in children with nocturnal frontal-lobe epilepsy.
Raju GP, Sarco DP, Poduri A, Riviello JJ, Bergin AM, Takeoka M

Neonatal subependymal giant cell astrocytoma: new case and review of literature.
Raju GP, Urion DK, Sahin M

SANE, a novel LEM domain protein, regulates bone morphogenetic protein signaling through interaction with Smad1.
Raju GP, Dimova N, Klein PS, Huang HC

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.