Eniko Sajti, M.D., Ph.D.

Bio

Dr. Eniko Sajti is a board-certified pediatrician and neonatologist at Rady Children's Hospital-San Diego. She is also an associate professor of pediatrics at UC San Diego School of Medicine.

She received her medical and doctoral degrees from Utrecht University in the Netherlands. As an awardee of the Dutch Royal Academy of Sciences, she completed a postdoctoral fellowship in pulmonary medicine at the University of California, San Francisco. After completing her pediatric residency and neonatology fellowship at Harvard Medical School/Boston Children's Hospital, she was recruited to UC San Diego Department of Pediatrics.

The Sajti lab's primary interests are to understand the molecular and cellular mechanisms controlling the development of the neonatal innate immune system. Current projects focus on determining the genetic and epigenetic signature of specialized innate immune cells in the neonatal lung and brain. To understand the relative contribution of various subtypes of innate immune cells to premature birth-related lung disease and impaired neurodevelopmental outcomes, Dr. Sajti employs genome-wide approaches and computational analyses to identify transcriptional and epigenetic mechanisms unique to each cell type. By elucidating disease and cell-type-specific gene regulatory networks, she hopes to develop new targeted therapies tailored to the needs of individual patients.

Publications

Universal Digital High-Resolution Melt Analysis for the Diagnosis of Bacteremia.
Aralar A, Goshia T, Ramchandar N, Lawrence SM, Karmakar A, Sharma A, Sinha M, Pride DT, Kuo P, Lecrone K, Chiu M, Mestan KK, Sajti E, Vanderpool M, Lazar S, Crabtree M, Tesfai Y, Fraley SI

Universal digital high resolution melt analysis for the diagnosis of bacteremia.
Aralar A, Goshia T, Ramchandar N, Lawrence SM, Karmakar A, Sharma A, Sinha M, Pride DT, Kuo P, Lecrone K, Chiu M, Mestan K, Sajti E, Vanderpool M, Lazar S, Crabtree M, Tesfai Y, Fraley SI

Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice.
Al-Mudares F, Cantu Gutierrez M, Cantu A, Jiang W, Wang L, Dong X, Moorthy B, Sajti E, Lingappan K

Leveraging the placenta to advance neonatal care.
Mestan KK, Leibel SL, Sajti E, Pham B, Hietalati S, Laurent L, Parast M

Remarkable sex-specific differences at single-cell resolution in neonatal hyperoxic lung injury.
Cantu A, Gutierrez MC, Dong X, Leek C, Sajti E, Lingappan K

The Lung Microenvironment Instructs Gene Transcription in Neonatal and Adult Alveolar Macrophages.
Honda A, Hoeksema MA, Sakai M, Lund SJ, Lakhdari O, Butcher LD, Rambaldo TC, Sekiya NM, Nasamran CA, Fisch KM, Sajti E, Glass CK, Prince LS

A census of the lung: CellCards from LungMAP.
Sun X, Perl AK, Li R, Bell SM, Sajti E, Kalinichenko VV, Kalin TV, Misra RS, Deshmukh H, Clair G, Kyle J, Crotty Alexander LE, Masso-Silva JA, Kitzmiller JA, Wikenheiser-Brokamp KA, Deutsch G, Guo M, Du Y, Morley MP, Valdez MJ, Yu HV, Jin K, Bardes EE, Zepp JA, Neithamer T, Basil MC, Zacharias WJ, Verheyden J, Young R, Bandyopadhyay G, Lin S, Ansong C, Adkins J, Salomonis N, Aronow BJ, Xu Y, Pryhuber G, Whitsett J, Morrisey EE, NHLBI LungMAP Consortium

Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes.
Wang A, Chiou J, Poirion OB, Buchanan J, Valdez MJ, Verheyden JM, Hou X, Kudtarkar P, Narendra S, Newsome JM, Guo M, Faddah DA, Zhang K, Young RE, Barr J, Sajti E, Misra R, Huyck H, Rogers L, Poole C, Whitsett JA, Pryhuber G, Xu Y, Gaulton KJ, Preissl S, Sun X, NHLBI LungMap Consortium

Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung.
Sajti E, Link VM, Ouyang Z, Spann NJ, Westin E, Romanoski CE, Fonseca GJ, Prince LS, Glass CK

An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner.
Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG

An environment-dependent transcriptional network specifies human microglia identity.
Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick SM, Glass CK

Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow.
Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR

Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow.
Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR

Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide.
Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR

Individual differences in behavior of inbred Lewis rats are associated with severity of joint destruction in adjuvant-induced arthritis.
Sajti E, van Meeteren N, Kavelaars A, van der Net J, Gispen WH, Heijnen C

Tumor angiogenesis and metastasis formation are associated with individual differences in behavior of inbred Lewis rats.
Sajti E, Kavelaars A, van Meeteren N, Teunis M, Gispen WH, Heijnen C

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

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