A. Preethi Ganesan, M.D., Ph.D.

Bio

Dr. Preethi Ganesan is a hematologist/oncologist at Rady Children's Hospital-San Diego and an adjunct assistant professor of pediatrics at UC San Diego School of Medicine. She provides inpatient care to patients with leukemia and lymphoma, which are her clinical interests.

Her research is focused on studying the dynamic interaction between the tumor immune-microenvironment and cancer stem cells that drive relapse. She seeks to investigate immune responses in pediatric tumors, with the ultimate goal of finding a novel immunotherapy.

During her fellowship at Rady Children's and UC San Diego, Dr. Ganesan evaluated the molecular profile of tumor-infiltrating lymphocytes isolated from patients with cancer and discovered that a distinct subset of T cells predict improved patient survival (in press, Nature Immunology). In her doctoral work, using patient tumor samples and a transgenic mouse model of cancer, she demonstrated the role of T regulatory cells in propelling tumor growth and mechanistically demonstrated that this was mediated by inhibition of anti-tumor CD8 cytotoxic T lymphocyte recruitment and function within tumors.

Dr. Ganesan completed her pediatric residency and doctoral program in tumor immunology, both in the United Kingdom. Among her honors and accomplishments, she received the Ray Owen Award for Outstanding Postdoctoral Scholar in 2017, a Hyundai Hope on Wheels Research Scholar grant in 2016 and a Berkeley Fellowship, awarded by University College London and Gonville & Caius College Cambridge, in 2013.

Publications

Intra-tumoral T cells in pediatric brain tumors display clonal expansion and effector properties.
Upadhye A, Meza Landeros KE, Ramírez-Suástegui C, Schmiedel BJ, Woo E, Chee SJ, Malicki D, Coufal NG, Gonda D, Levy ML, Greenbaum JA, Seumois G, Crawford J, Roberts WD, Schoenberger SP, Cheroutre H, Ottensmeier CH, Vijayanand P, Ganesan AP

Melanoma-reactive T cells take up residence.
Ganesan AP, Ottensmeier CHH

M1(hot) tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.
Garrido-Martin EM, Mellows TWP, Clarke J, Ganesan AP, Wood O, Cazaly A, Seumois G, Chee SJ, Alzetani A, King EV, Hedrick CC, Thomas G, Friedmann PS, Ottensmeier CH, Vijayanand P, Sanchez-Elsner T

NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors.
Ford K, Hanley CJ, Mellone M, Szyndralewiez C, Heitz F, Wiesel P, Wood O, Machado M, Lopez MA, Ganesan AP, Wang C, Chakravarthy A, Fenton TR, King EV, Vijayanand P, Ottensmeier CH, Al-Shamkhani A, Savelyeva N, Thomas GJ

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer.
Clarke J, Panwar B, Madrigal A, Singh D, Gujar R, Wood O, Chee SJ, Eschweiler S, King EV, Awad AS, Hanley CJ, McCann KJ, Bhattacharyya S, Woo E, Alzetani A, Seumois G, Thomas GJ, Ganesan AP, Friedmann PS, Sanchez-Elsner T, Ay F, Ottensmeier CH, Vijayanand P

Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment.
Chandra S, Wingender G, Greenbaum JA, Khurana A, Gholami AM, Ganesan AP, Rosenbach M, Jaffee K, Gern JE, Wood R, O'Connor G, Sandel M, Kattan M, Bacharier L, Togias A, Horner AA, Kronenberg M

Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma.
Lazzari E, Mondala PK, Santos ND, Miller AC, Pineda G, Jiang Q, Leu H, Ali SA, Ganesan AP, Wu CN, Costello C, Minden M, Chiaramonte R, Stewart AK, Crews LA, Jamieson CHM

Obstructive sleep apnoea as a presenting manifestation of non-Hodgkin lymphoma in a child.
Ganesan AP, Jiang W, Kuo DJ, Bhattacharjee R

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.
Ganesan AP, Clarke J, Wood O, Garrido-Martin EM, Chee SJ, Mellows T, Samaniego-Castruita D, Singh D, Seumois G, Alzetani A, Woo E, Friedmann PS, King EV, Thomas GJ, Sanchez-Elsner T, Vijayanand P, Ottensmeier CH

Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma.
Ganesan AP, Johansson M, Ruffell B, Yagui-Beltrán A, Lau J, Jablons DM, Coussens LM

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.