Adriana Tremoulet, M.D.

Specialty

Kawasaki Disease

Organization

Rady Children's Specialists of San Diego

Medical Group / IPA

CPMG/RCHN/RCSSD

Medical School

University of California Los Angeles

Residency

Cedars-Sinai Medical Center

Fellowship

UC San Diego

Board Certifications

Pediatric Infectious Diseases, Pediatrics

Bio

Dr. Adriana Tremoulet is the associate director of the Kawasaki Disease Research Center at UC San Diego. In this role, she cares for nearly 1,500 children with Kawasaki disease in San Diego County and an additional 90 children a year hospitalized at Rady Children's Hospital-San Diego .

Dr. Tremoulet graduated from Harvard University with a major in biochemistry and attended medical school at the University of California, Los Angeles. During medical school, she spent a year as a fellow in the National Institutes of Health Clinical Research Training Program. She then completed her residency at Cedars-Sinai Medical Center and her pediatric infectious disease fellowship at UC San Diego.

In 2013, Dr. Tremoulet was appointed as the associate director of clinical research at Rady Children's. She is also the site principal investigator for the National Institute of Child Health and Human Development-funded Pediatric Trials Network and Research Program in Developmental Pharmacology at UC San Diego. Dr. Tremoulet has led Phase I through III clinical trials, including a Food and Drug Administration Orphan Products grant-funded Phase III clinical trial on the use of infliximab as adjunctive primary therapy in Kawasaki disease.

Publications

Risk Model Development and Validation for Prediction of Coronary Artery Aneurysms in Kawasaki Disease in a North American Population.
Son MBF, Gauvreau K, Tremoulet AH, Lo M, Baker AL, de Ferranti S, Dedeoglu F, Sundel RP, Friedman KG, Burns JC, Newburger JW

HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease.
Shimizu C, Kim J, Eleftherohorinou H, Wright VJ, Hoang LT, Tremoulet AH, Franco A, Hibberd ML, Takahashi A, Kubo M, Ito K, Tanaka T, Onouchi Y, Coin LJM, Levin M, Burns JC, Shike H, International Kawasaki Disease Genetic Consortium.

Author Correction: Clustering and climate associations of Kawasaki Disease in San Diego County suggest environmental triggers.
Rypdal M, Rypdal V, Burney JA, Cayan D, Bainto E, Skochko S, Tremoulet AH, Creamean J, Shimizu C, Kim J, Burns JC

Treatment Intensification in Patients With Kawasaki Disease and Coronary Aneurysm at Diagnosis.
Dionne A, Burns JC, Dahdah N, Tremoulet AH, Gauvreau K, de Ferranti SD, Baker AL, Son MB, Gould P, Fournier A, Newburger JW, Friedman KG

Circulating Markers of Inflammation Persist in Children and Adults With Giant Aneurysms After Kawasaki Disease.
Lech M, Guess J, Duffner J, Oyamada J, Shimizu C, Hoshino S, Farutin V, Bulik DA, Gutierrez B, Sarvaiya H, Kapoor B, Koppes L, Saldova R, Stockmann H, Albrecht S, McManus C, Rudd PM, Kaundinya GV, Manning AM, Bosques CJ, Kahn AM, Daniels LB, Gordon JB, Tremoulet AH, Capila I, Gunay NS, Ling LE, Burns JC

The Kawasaki Disease Comparative Effectiveness (KIDCARE) trial: A phase III, randomized trial of second intravenous immunoglobulin versus infliximab for resistant Kawasaki disease.
Roberts SC, Jain S, Tremoulet AH, Kim KK, Burns JC, KIDCARE Multicenter Study Group., Anand V, Anderson M, Ang J, Ansusinha E, Arditi M, Ashouri N, Bartlett A, Chatterjee A, DeBiasi R, Dekker C, DeZure C, Didion L, Dominguez S, El Feghaly R, Erdem G, Halasa N, Harahsheh A, Jackson MA, Jaggi P, Jain S, Jone PN, Kaushik N, Kurio G, Lillian A, Lloyd D, Manaloor J, McNelis A, Michalik DE, Newburger J, Newcomer C, Perkins T, Portman M, Romero J, Ronis T, Rowley A, Schneider K, Schuster J, Tejtel SKS, Sharma K, Simonsen K, Szmuszkovicz J, Truong D, Wood J, Yeh S

Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence.
Liang H, Tsui BY, Ni H, Valentim CCS, Baxter SL, Liu G, Cai W, Kermany DS, Sun X, Chen J, He L, Zhu J, Tian P, Shao H, Zheng L, Hou R, Hewett S, Li G, Liang P, Zang X, Zhang Z, Pan L, Cai H, Ling R, Li S, Cui Y, Tang S, Ye H, Huang X, He W, Liang W, Zhang Q, Jiang J, Yu W, Gao J, Ou W, Deng Y, Hou Q, Wang B, Yao C, Liang Y, Zhang S, Duan Y, Zhang R, Gibson S, Zhang CL, Li O, Zhang ED, Karin G, Nguyen N, Wu X, Wen C, Xu J, Xu W, Wang B, Wang W, Li J, Pizzato B, Bao C, Xiang D, He W, He S, Zhou Y, Haw W, Goldbaum M, Tremoulet A, Hsu CN, Carter H, Zhu L, Zhang K, Xia H

Clustering and climate associations of Kawasaki Disease in San Diego County suggest environmental triggers.
Rypdal M, Rypdal V, Burney JA, Cayan D, Bainto E, Skochko S, Tremoulet AH, Creamean J, Shimizu C, Kim J, Burns JC

Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis.
Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR

Bifid T waves on the ECG and genetic variation in calcium channel voltage-dependent beta 2 subunit gene (CACNB2) in acute Kawasaki disease.
Oyamada J, Shimizu C, Kim J, Williams MR, Png E, Hibberd ML, Tremoulet AH, Perry JC, Burns JC

Association of Initially Normal Coronary Arteries With Normal Findings on Follow-up Echocardiography in Patients With Kawasaki Disease.
de Ferranti SD, Gauvreau K, Friedman KG, Tang A, Baker AL, Fulton DR, Tremoulet AH, Burns JC, Newburger JW

Kawasaki Disease Outcomes and Response to Therapy in a Multiethnic Community: A 10-Year Experience.
Skochko SM, Jain S, Sun X, Sivilay N, Kanegaye JT, Pancheri J, Shimizu C, Sheets R, Tremoulet AH, Burns JC

Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature.
Wright VJ, Herberg JA, Kaforou M, Shimizu C, Eleftherohorinou H, Shailes H, Barendregt AM, Menikou S, Gormley S, Berk M, Hoang LT, Tremoulet AH, Kanegaye JT, Coin LJM, Glodé MP, Hibberd M, Kuijpers TW, Hoggart CJ, Burns JC, Levin M, Immunopathology of Respiratory, Inflammatory and Infectious Disease Study (IRIS) Consortium and the Pediatric Emergency Medicine Kawasaki Disease Research Group (PEMKDRG).

Whole blood transcriptional profiles as a prognostic tool in complete and incomplete Kawasaki Disease.
Jaggi P, Mejias A, Xu Z, Yin H, Moore-Clingenpeel M, Smith B, Burns JC, Tremoulet AH, Jordan-Villegas A, Chaussabel D, Texter K, Pascual V, Ramilo O

Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease.
Vande Casteele N, Oyamada J, Shimizu C, Best BM, Capparelli EV, Tremoulet AH, Burns JC

Development of Tolerance to Chronic Intermittent Furosemide Therapy in Pediatric Patients.
Kim GJ, Capparelli E, Romanowski G, Proudfoot JA, Tremoulet AH

Pediatric tolerogenic DCs expressing CD4 and immunoglobulin-like transcript receptor (ILT)-4 secrete IL-10 in response to Fc and adenosine.
Franco A, Kumar J, Lin G, Behnamfar N, Hsieh LE, Shimizu C, Tremoulet AH, Burns JC, Linden J

Adjunctive therapies in Kawasaki disease.
Tremoulet AH

Fever without a source: evolution of a diagnosis from Kawasaki disease to acute myelogenous leukaemia.
Lee B, Kofman CD, Tremoulet AH, Kuo DJ

High Risk of Coronary Artery Aneurysms in Infants Younger than 6 Months of Age with Kawasaki Disease.
Salgado AP, Ashouri N, Berry EK, Sun X, Jain S, Burns JC, Tremoulet AH

Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility.
Kim J, Shimizu C, Kingsmore SF, Veeraraghavan N, Levy E, Ribeiro Dos Santos AM, Yang H, Flatley J, Hoang LT, Hibberd ML, Tremoulet AH, Harismendy O, Ohno-Machado L, Burns JC

Unique Molecular Patterns Uncovered in Kawasaki Disease Patients with Elevated Serum Gamma Glutamyl Transferase Levels: Implications for Intravenous Immunoglobulin Responsiveness.
Wang Y, Li Z, Hu G, Hao S, Deng X, Huang M, Ren M, Jiang X, Kanegaye JT, Ha KS, Lee J, Li X, Jiang X, Yu Y, Tremoulet AH, Burns JC, Whitin JC, Shin AY, Sylvester KG, McElhinney DB, Cohen HJ, Ling XB, Pediatric Emergency Medicine Kawasaki Disease Research Group.

miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease.
He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet AH, Shimizu C, Jain MK, Burns JC, Shyy JY

Safety of Infliximab Following Live Virus Vaccination in Kawasaki Disease Patients.
Lee AM, Burns JC, Tremoulet AH

Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities.
Shimizu C, Eleftherohorinou H, Wright VJ, Kim J, Alphonse MP, Perry JC, Cimaz R, Burgner D, Dahdah N, Hoang LT, Khor CC, Salgado A, Tremoulet AH, Davila S, Kuijpers TW, Hibberd ML, Johnson TA, Takahashi A, Tsunoda T, Kubo M, Tanaka T, Onouchi Y, Yeung RS, Coin LJ, Levin M, Burns JC, International Kawasaki Disease Genetics Consortium.

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

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