Karen Mestan, M.D., M.S.

Bio

Dr. Karen Mestan is chief of the Division of Neonatology in the Department of Pediatrics at Rady Children’s Hospital-San Diego and UC San Diego School of Medicine.

Her clinical focus is on the management of critically ill newborn infants cared for in the neonatal intensive care unit, including premature newborns and infants with congenital conditions and complex medical diagnoses.

Her research, funded by the National Institutes of Health, seeks to understand the mechanisms of infant chronic lung diseases, such as bronchopulmonary dysplasia and neonatal pulmonary hypertension. Specifically, Dr. Mestan aims to identify the early biochemical, environmental and genetic markers of preterm birth. These discoveries can lead to new approaches and therapies to improve long-term cardiovascular and lung health, as well as metabolic and neurodevelopmental outcomes in infancy and early childhood.

Publications

Bronchopulmonary dysplasia: signatures of monocyte-macrophage reactivity and tolerance define novel placenta-lung endotypes.
Mestan KK, Sharma AM, Lazar S, Pandey S, Parast MM, Laurent LC, Prince LS, Sahoo D

Evolution of the umbilical cord blood proteome across gestational development.
Mithal LB, Lancki N, Ling-Hu T, Goo YA, Otero S, Rhodes NJ, Cho BK, Grobman WA, Hultquist JF, Scholtens D, Mestan KK, Seed PC

Placental pathology and fetal growth outcomes in pregnancies complicated by maternal obesity.
Hietalati S, Pham D, Arora H, Mochizuki M, Santiago G, Vaught J, Lin ET, Mestan KK, Parast M, Jacobs MB

Evolution of the Umbilical Cord Blood Proteome Across Gestational Development.
Mithal LB, Lancki N, Ling-Hu T, Goo YA, Otero S, Rhodes NJ, Cho BK, Grobman WA, Hultquist JF, Scholtens D, Mestan KG, Seed PC

Universal Digital High-Resolution Melt Analysis for the Diagnosis of Bacteremia.
Aralar A, Goshia T, Ramchandar N, Lawrence SM, Karmakar A, Sharma A, Sinha M, Pride DT, Kuo P, Lecrone K, Chiu M, Mestan KK, Sajti E, Vanderpool M, Lazar S, Crabtree M, Tesfai Y, Fraley SI

Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia.
Lin ET, Bae Y, Birkett R, Sharma AM, Zhang R, Fisch KM, Funk W, Mestan KK

Maternal-Fetal Connections in Prenatal Respiratory Disease: Time to Address Intrauterine Inflammation.
Taglauer ES, Mestan KK

Macrophage Polarizations in the Placenta and Lung are Associated with Bronchopulmonary Dysplasia.
Mestan KK, Sharma A, Lazar S, Pandey S, Parast MM, Laurent LC, Prince LS, Sahoo D

Bilateral Renal Agenesis-Interpreting the RAFT Trial.
Gyamfi-Bannerman C, Marc-Aurele K, Mestan K

Universal digital high resolution melt analysis for the diagnosis of bacteremia.
Aralar A, Goshia T, Ramchandar N, Lawrence SM, Karmakar A, Sharma A, Sinha M, Pride DT, Kuo P, Lecrone K, Chiu M, Mestan K, Sajti E, Vanderpool M, Lazar S, Crabtree M, Tesfai Y, Fraley SI

Development of a novel humanized mouse model to study bronchopulmonary dysplasia.
Birkett R, Newar J, Sharma AM, Lin E, Blank L, Swaminathan S, Misharin A, Mestan KK

Fundamentals in neonatologist staffing: transparency, autonomy, and partnership.
Suttner D, Mestan K, Steinhorn R

Leveraging the placenta to advance neonatal care.
Mestan KK, Leibel SL, Sajti E, Pham B, Hietalati S, Laurent L, Parast M

Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease.
Redline RW, Roberts DJ, Parast MM, Ernst LM, Morgan TK, Greene MF, Gyamfi-Bannerman C, Louis JM, Maltepe E, Mestan KK, Romero R, Stone J

Family and Provider Experiences With Longitudinal Care Coordination for Infants With Medical Complexity.
Dallas A, Ryan A, Mestan K, Helner K, Foster C

Lability of prenatal stress during the COVID-19 pandemic links to negative affect in infancy.
MacNeill LA, Krogh-Jespersen S, Zhang Y, Giase G, Edwards R, Petitclerc A, Mithal LB, Mestan K, Grobman WA, Norton ES, Alshurafa N, Moskowitz JT, Tandon SD, Wakschlag LS

Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth.
Sharma AM, Birkett R, Lin ET, Ernst LM, Grobman WA, Swaminathan S, Abdala-Valencia H, Misharin AV, Bartom ET, Mestan KK

Umbilical cord miRNAs to predict neonatal early onset sepsis.
Ernst LM, Mithal LB, Mestan K, Wang V, Mangold KA, Freedman A, Das S

Moving the dial on prenatal stress mechanisms of neurodevelopmental vulnerability to mental health problems: A personalized prevention proof of concept.
Wakschlag LS, Tandon D, Krogh-Jespersen S, Petitclerc A, Nielsen A, Ghaffari R, Mithal L, Bass M, Ward E, Berken J, Fareedi E, Cummings P, Mestan K, Norton ES, Grobman W, Rogers J, Moskowitz J, Alshurafa N

Understanding Racial Disparities of Preterm Birth Through the Placenta.
Matoba N, Mestan KK, Collins JW Jr

Placental vascular maldevelopment, intrauterine growth restriction, and pulmonary hypertension.
Mathias M, Bitar M, Aldulescu M, Birkett R, Perez M, Mestan K

Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants.
Batlahally S, Franklin A, Damianos A, Huang J, Chen P, Sharma M, Duara J, Keerthy D, Zambrano R, Shehadeh LA, Martinez EC, DeFreitas MJ, Kulandavelu S, Abitbol CL, Freundlich M, Kanashiro-Takeuchi RM, Schmidt A, Benny M, Wu S, Mestan KK, Young KC

The impact of placental pathology discordance in multiple gestation pregnancies on bronchopulmonary dysplasia-associated pulmonary hypertension.
Franklin A, Yallapragada S, Birkett R, Grobman W, Ernst LM, Mestan K

Variations in Umbilical Cord Hematopoietic and Mesenchymal Stem Cells With Bronchopulmonary Dysplasia.
Chaudhury S, Saqibuddin J, Birkett R, Falcon-Girard K, Kraus M, Ernst LM, Grobman W, Mestan KK

Cord blood alpha klotho is decreased in small for gestational age preterm infants with placental lesions of accelerated aging.
Franklin AD, Saqibuddin J, Stephens K, Birkett R, Marsden L, Ernst LM, Mestan KK

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.