3020 Children's Way
San Diego, CA 92123
Rady Children's Specialists of San Diego
State University of New York at Buffalo (Medicine)
UC San Diego
UC San Diego
Dr. Lori Broderick is a board-certified allergist/immunologist at Rady Children's Hospital-San Diego and an assistant professor of pediatrics at UC San Diego, with specific interests in disorders of pediatric immunity.
Dr. Broderick earned her undergraduate degree from Syracuse University in New York, graduating summa cum laude. She then received her doctorate in tumor immunology and her medical degree at the University of Buffalo in New York. She completed her pediatric residency at UC San Diego, where she developed an interest in patients with primary immunodeficiencies and autoinflammatory syndromes, also known as periodic fever disorders. She then completed a fellowship in allergy and immunology at UC San Diego, receiving extensive training to diagnose and manage primary immunodeficiency, allergic disorders and autoinflammation.
At UC San Diego, Dr. Broderick performs translational research to study the genetics and inflammatory etiology of autoinflammatory disorders, specifically periodic fever, aphthosus stomatitis, pharyngitis and adenitis (PFAPA) syndrome, as well as the identification of novel immunodeficiencies.
Dr. Broderick is the recipient of a number of distinctions and research awards from organizations including the American Academy of Pediatrics, the Thrasher Research Fund, The Hartwell Foundation, the A.P. Giannini Foundation and the Arthritis National Research Foundation. She is an active member of the American Academy of Allergy, Asthma, and Immunology; the International Society of Systemic Auto-Inflammatory Diseases; the Clinical Immunology Society and the San Diego Allergy Society.
Disease-associated mutations in topoisomerase IIÎ² result in defective NK cells.
Broderick L, Clay GM, Blum RH, Liu Y, McVicar R, Papes F, Booshehri LM, Cowell IG, Austin CA, Putnam CD, Kaufman DS
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome.
Stackowicz J, Gaudenzio N, Serhan N, Conde E, Godon O, Marichal T, Starkl P, Balbino B, Roers A, Bruhns P, JÃ¶nsson F, Moguelet P, Georgin-Lavialle S, Broderick L, Hoffman HM, Galli SJ, Reber LL
Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C.
Zhu YP, Shamie I, Lee JC, Nowell CJ, Peng W, Angulo S, Le LN, Liu Y, Miao H, Xiong H, Pena CJ, Moreno E, Griffis E, Labou SG, Franco A, Broderick L, Hoffman HM, Shimizu C, Lewis NE, Kanegaye JT, Tremoulet AH, Burns JC, Croker BA, Pediatric Emergency Medicine Kawasaki Disease Research Group Consortium.
Undifferentiated recurrent fevers in pediatrics are clinically distinct from PFAPA syndrome but retain an IL-1 signature.
Luu I, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Pransky S, Broderick L
Immune Dysregulation in the Tonsillar Microenvironment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome.
Luu I, Sharma A, Guaderrama M, Peru M, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Newbury R, Pransky S, Gilbert JA, Broderick L
Mutations in topoisomerase IIÎ² result in a B cell immunodeficiency.
Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, HÃ¼gle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM
Alternative splicing regulates stochastic NLRP3 activity.
Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E
JAK inhibitors in autoinflammation.
Hoffman HM, Broderick L
TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies.
McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, PeÃ±a CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM
NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy.
Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ
Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report.
Radhakrishna SM, Grimm A, Broderick L
Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease.
Hoffman HM, Broderick L
The role of the inflammasome in patients with autoinflammatory diseases.
Hoffman HM, Broderick L
NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.
Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, PeÃ±a CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G
The inflammasomes and autoinflammatory syndromes.
Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E
Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.
Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T
Broderick L, Hoffman HM
Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.
Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM
Recurrent fevers and failure to thrive in an infant.
Scott DR, Chan S, Chang J, Broderick L, Hoffman HM
From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.
Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE
Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis.
Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF
Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models.
McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD
See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.
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