San Diego County

3020 Children's Way
MC 5004
San Diego, CA 92123




Rady Children's Specialists of San Diego

Medical Group / IPA


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Medical School

University of Texas


UC San Diego


UC San Diego


UC San Diego

Board Certifications

Pediatric Cardiology, Pediatrics




Dr. Paul Grossfeld is a board-certified pediatric cardiologist at Rady Children's Hospital-San Diego and a professor of pediatrics at UC San Diego School of Medicine. He treats both pediatric and adult patients with congenital heart disease.

After earning his medical degree at the University of Texas Southwestern School of Medicine in 1992, he went on to complete his pediatrics residency training in 1995 at UC San Diego, followed by a pediatric cardiology fellowship at UC San Diego in 1999.

Dr. Grossfeld has a particular interest in treating patients with rare genetic syndromes, including Jacobsen syndrome, Marfan syndrome and Williams syndrome. He serves as the chief medical advisor for the 11q Research and Resource Group as well as the European Chromosome 11 support group. He also directs a basic science research laboratory at UC San Diego dedicated to studying genetic causes of congenital heart disease, with a specific focus on hypoplastic left heart syndrome. Dr. Grossfeld has nearly 70 peer-reviewed publications.

Along with his clinical and research responsibilities, Dr. Grossfeld served for 12 years as the director of the UC San Diego/Rady Children’s Pediatric Cardiology Fellowship Program and continues to be actively engaged in teaching and mentoring fellows, residents, medical, undergraduate and high school students. He also serves as a volunteer cardiologist for the United States Men’s’ and Women’s’ Olympic Volleyball teams. Among his professional activities, he and his wife, Susan, have led annual cardiac missions to the Angkor Hospital for Children in Siem Reap, Cambodia.

When not working, Dr. Grossfeld enjoys spending time with his wife and son, traveling, working out, playing tennis and golf, and swimming in La Jolla cove.


Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity.
Birker K, Ge S, Kirkland NJ, Theis JL, Marchant J, Fogarty ZC, Missinato MA, Kalvakuri S, Grossfeld P, Engler AJ, Ocorr K, Nelson TJ, Colas AR, Olson TM, Vogler G, Bodmer R

Isolated Absent Aortic Valves: A Unique Fetal Case With Echocardiographic, Pathologic, and Genetic Correlation.
Schuchardt EL, Grossfeld P, Kingsmore S, Ding Y, Vargas LA, Dyar DA, Mendoza A, Dummer KB

ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.
Lin L, Pinto A, Wang L, Fukatsu K, Yin Y, Bamforth SD, Bronner ME, Evans SM, Nie S, Anderson RH, Terskikh AV, Grossfeld PD

Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
Wang L, Lin L, Qi H, Chen J, Grossfeld P

ETS1 and HLHS: Implications for the Role of the Endocardium.
Grossfeld P

High Level of Serum Uric Acid induced Monocyte Inflammation is Related to Coronary Calcium Deposition in the Middle-Aged and Elder Population of China: A five-year Prospective Cohort Study.
Wang X, Liu X, Qi Y, Zhang S, Shi K, Lin H, Grossfeld P, Wang W, Wu T, Qu X, Xiao J, Ye M

Successful Management of a Patient With Jacobsen Syndrome and Hypoplastic Left Heart Syndrome.
Herrick NL, Lamberti J, Grossfeld P, Murthy R

Combined Non-Invasive Cardiac Imaging and Genetic Testing of Elite Volleyball Players: A Ten-Year Experience.
Grossfeld P

The Needle in the Haystack-Searching for Genetic and Epigenetic Differences in Monozygotic Twins Discordant for Tetralogy of Fallot.
Grunert M, Appelt S, Grossfeld P, Sperling SR

Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome.
Theis JL, Vogler G, Missinato MA, Li X, Nielsen T, Zeng XI, Martinez-Fernandez A, Walls SM, Kervadec A, Kezos JN, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Nelson TJ, Olson TM, Colas AR, Bodmer R

Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome.
Miao Y, Tian L, Martin M, Paige SL, Galdos FX, Li J, Klein A, Zhang H, Ma N, Wei Y, Stewart M, Lee S, Moonen JR, Zhang B, Grossfeld P, Mital S, Chitayat D, Wu JC, Rabinovitch M, Nelson TJ, Nie S, Wu SM, Gu M

Arterial Switch Operation in a Patient With Ehlers-Danlos Syndrome Type IV.
Murthy R, Herrick NL, El-Said H, Grossfeld P, Moore J, Lamberti JJ

Overexpression of Kif1A in the Developing Drosophila Heart Causes Valvar and Contractility Defects: Implications for Human Congenital Heart Disease.
Akasaka T, Ocorr K, Lin L, Vogler G, Bodmer R, Grossfeld P

Model system identification of novel congenital heart disease gene candidates: focus on RPL13.
Schroeder AM, Allahyari M, Vogler G, Missinato MA, Nielsen T, Yu MS, Theis JL, Larsen LA, Goyal P, Rosenfeld JA, Nelson TJ, Olson TM, Colas AR, Grossfeld P, Bodmer R

Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition.
Xu L, Fu M, Chen D, Han W, Ostrowski MC, Grossfeld P, Gao P, Ye M

Partial Jacobsen syndrome phenotype in a patient with a de novo frameshift mutation in the ETS1 transcription factor.
Tootleman E, Malamut B, Akshoomoff N, Mattson SN, Hoffman HM, Jones MC, Printz B, Shiryaev SA, Grossfeld P

Hypoplastic Left Heart Syndrome: A New Paradigm for an Old Disease?
Grossfeld P, Nie S, Lin L, Wang L, Anderson RH

Gene-targeted deletion in mice of the Ets-1 transcription factor, a candidate gene in the Jacobsen syndrome kidney "critical region," causes abnormal kidney development.
Ye M, Xu L, Fu M, Chen D, Mattina T, Zufardi O, Rossi E, Bush KT, Nigam SK, Grossfeld P

Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion.
van Vliet PP, Lin L, Boogerd CJ, Martin JF, Andelfinger G, Grossfeld PD, Evans SM

The complex genetics of hypoplastic left heart syndrome.
Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA Jr, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW

Utility of Genetic Testing in Elite Volleyball Players with Aortic Root Dilation.
Herrick N, Davis C, Vargas L, Dietz H, Grossfeld P

Brain hemorrhages in Jacobsen syndrome: A retrospective review of six cases and clinical recommendations.
Grossfeld P

Evidence That Deletion of ETS-1, a Gene in the Jacobsen Syndrome (11q-) Cardiac Critical Region, Causes Congenital Heart Defects through Impaired Cardiac Neural Crest Cell Function.
Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, Ye M, Yin Y, Fukatsu K, Grossfeld P

PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking.
Nakamura T, Arima-Yoshida F, Sakaue F, Nasu-Nishimura Y, Takeda Y, Matsuura K, Akshoomoff N, Mattson SN, Grossfeld PD, Manabe T, Akiyama T

Transcriptional Impact of Rare and Private Copy Number Variants in Hypoplastic Left Heart Syndrome.
Glidewell SC, Miyamoto SD, Grossfeld PD, Clouthier DE, Coldren CD, Stearman RS, Geraci MW

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.

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