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Lab Test Dictionary

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Antibody, IgG (2013101)

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Synonyms

HMG

Specimen Type

Serum

Performing Lab

ARUP

Epic ID

Other Reference Test

Lab Test Days

Friday

Standard TAT

1-8 Days

Collection Information

Specimen Required

1 mL Blood

Container Type

Serum Separator Tube (SST)

Processing Information - Lab Use Only

Transport Temperature

Refrigerated-OK/Frozen-OK

Specimen Stability

Room Temp: 1 Day; Refrigerated: 2 Weeks (Preferred); Frozen: 1 Year

Rejection Criteria

Other body fluids; Contaminated; Hemolyzed; Grossly icteric or severely lipemic specimens

Test Volume Required

0.5 mL Serum

Minimum Test Volume

0.15 mL Serum

Processing Instructions

Complete an ARUP requisition form and submit serum refrigerated with daily Apollo Courier pick up.

Comments

IgG antibodies to HMGCR are mainly associated with necrotizing autoimmune myopathy (NAM) in a subset of statin-treated patients. Although infrequest, these antibodies may also be observd in statin-naive patients with NAM. Strong clinical correlation is recommended in the absence of muscle fiber necrosis, elevated serum creatinine kinase, perimysial pathology, and/or statin exposure.