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Lab Test Dictionary
3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Antibody, IgG (2013101)
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Synonyms
HMG
Specimen Type
Blood
Performing Lab
ARUP
Epic ID
Other Reference Test
Lab Test Days
Fri
Standard TAT
1-15 Days
Collection Information
Specimen Required
2 mL blood
Container Type
Red Top with Gel Barrier
Processing Information - Lab Use Only
Transport Temperature
Refrigerated
Specimen Stability
After separation from cells: Room Temp=48 hours, Refrigerated=2 weeks, Frozen=1 year
Rejection Criteria
Other body fluids. Contaminated, hemolyzed, grossly icteric or severely lipemic specimens.
Test Volume Required
0.5 mL serum
Minimum Test Volume
0.15 mL serum
Processing Instructions
Centrifuge & separate serum
Comments
IgG antibodies to HMGCR are mainly associated with necrotizing autoimmune myopathy (NAM) in a subset of statin-treated patients. Although infrequest, these antibodies may also be observd in statin-naive patients with NAM. Strong clinical correlation is recommended in the absence of muscle fiber necrosis, elevated serum creatinine kinase, perimysial pathology, and/or statin exposure.
CPT Codes
83516
Initials
cas 10/11/23