Jong Rho, M.D.

Bio

Dr. Rho is the division chief of neurology at Rady Children's Hospital-San Diego and a professor of neurosciences and pediatrics at UC San Diego School of Medicine.

His clinical expertise is in general pediatric neurology and pediatric epilepsy, with an emphasis on pharmacological therapies and metabolic approaches toward epilepsy treatment, such as the ketogenic diet. His main research interests for patients, including at Rady Children’s Hospital-San Diego, are the mechanisms underlying the anti-seizure and neuroprotective effects of the ketogenic diet and its clinical variants. Dr. Rho's research activities involving patient care and treating neurological conditions have been funded by grants from the National Institutes of Health, Canadian Institutes of Health Research, Brain Canada and a variety of intramural and extramural public and private sector sources.

Prior to his current position proving patient care as chief of pediatric neurology at Rady Children’s Hospital-San Diego, Dr. Rho held full-time academic faculty appointments at the University of Washington (Seattle) and Seattle Children's Hospital; the University of California at Irvine; the University of Arizona and Arizona State University (Barrow Neurological Institute in Phoenix); and most recently, the Alberta Children's Hospital and the University of Calgary (Alberta, Canada).

Dr. Rho completed residency training in pediatrics at Children's Hospital Los Angeles (affiliated with the University of Southern California), followed by adult neurology and pediatric neurology residency/fellowship training at the University of California Los Angeles Medical Center (David Geffen School of Medicine at UCLA). He also completed a research fellowship in neuropharmacology at the National Institutes of Health. Dr. Rho received his undergraduate degree in molecular biophysics and biochemistry from Yale University and his medical degree from the University of Cincinnati.

Publications

Postictal hypoxia involves reactive oxygen species and is ameliorated by chronic mitochondrial uncoupling.
Villa BR, George AG, Shutt TE, Sullivan PG, Rho JM, Teskey GC

Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming.
Agarwal D, Dash N, Mazo KW, Chopra M, Avila MP, Patel A, Wong RM, Jia C, Do H, Cheng J, Chiang C, Jurlina SL, Roshan M, Perry MW, Rho JM, Broyer R, Lee CD, Weinreb RN, Gavrilovici C, Oesch NW, Welsbie DS, Wahlin KJ

Intermittent vs continuous ketogenic diet: Impact on seizures, gut microbiota, and mitochondrial metabolism.
Shearer J, Scantlebury MH, Rho JM, Tompkins TA, Mu C

Proposed anti-seizure medication combinations with rufinamide in the treatment of Lennox-Gastaut syndrome: Narrative review and expert opinion.
Sankar R, Chez M, Pina-Garza JE, Dixon-Salazar T, Flamini JR, Hyslop A, McGoldrick P, Millichap JJ, Resnick T, Rho JM, Wolf S

kcna1a mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and show response to first-line therapy carbamazepine.
Dogra D, Meza-Santoscoy PL, Gavrilovici C, Rehak R, de la Hoz CLR, Ibhazehiebo K, Rho JM, Kurrasch DM

Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia.
George AG, Farrell JS, Colangeli R, Wall AK, Gom RC, Kesler MT, Rodriguez de la Hoz C, Villa BR, Perera T, Rho JM, Kurrasch D, Teskey GC

A clinically relevant selective ERK-pathway inhibitor reverses core deficits in a mouse model of autism.
Murari K, Abushaibah A, Rho JM, Turner RW, Cheng N

Cannabidiol Impairs Brain Mitochondrial Metabolism and Neuronal Integrity.
Drummond-Main CD, Ahn Y, Kesler M, Gavrilovici C, Kim DY, Kiroski I, Baglot SL, Chen A, Sharkey KA, Hill MN, Teskey GC, Rho JM

Circadian Responses to Light in the BTBR Mouse.
Vijaya Shankara J, Horsley KG, Cheng N, Rho JM, Antle MC

Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications.
Johannesen KM, Liu Y, Koko M, Gjerulfsen CE, Sonnenberg L, Schubert J, Fenger CD, Eltokhi A, Rannap M, Koch NA, Lauxmann S, Krüger J, Kegele J, Canafoglia L, Franceschetti S, Mayer T, Rebstock J, Zacher P, Ruf S, Alber M, Sterbova K, Lassuthová P, Vlckova M, Lemke JR, Platzer K, Krey I, Heine C, Wieczorek D, Kroell-Seger J, Lund C, Klein KM, Au PYB, Rho JM, Ho AW, Masnada S, Veggiotti P, Giordano L, Accorsi P, Hoei-Hansen CE, Striano P, Zara F, Verhelst H, Verhoeven JS, Braakman HMH, van der Zwaag B, Harder AVE, Brilstra E, Pendziwiat M, Lebon S, Vaccarezza M, Le NM, Christensen J, Grønborg S, Scherer SW, Howe J, Fazeli W, Howell KB, Leventer R, Stutterd C, Walsh S, Gerard M, Gerard B, Matricardi S, Bonardi CM, Sartori S, Berger A, Hoffman-Zacharska D, Mastrangelo M, Darra F, Vøllo A, Motazacker MM, Lakeman P, Nizon M, Betzler C, Altuzarra C, Caume R, Roubertie A, Gélisse P, Marini C, Guerrini R, Bilan F, Tibussek D, Koch-Hogrebe M, Perry MS, Ichikawa S, Dadali E, Sharkov A, Mishina I, Abramov M, Kanivets I, Korostelev S, Kutsev S, Wain KE, Eisenhauer N, Wagner M, Savatt JM, Müller-Schlüter K, Bassan H, Borovikov A, Nassogne MC, Destrée A, Schoonjans AS, Meuwissen M, Buzatu M, Jansen A, Scalais E, Srivastava S, Tan WH, Olson HE, Loddenkemper T, Poduri A, Helbig KL, Helbig I, Fitzgerald MP, Goldberg EM, Roser T, Borggraefe I, Brünger T, May P, Lal D, Lederer D, Rubboli G, Heyne HO, Lesca G, Hedrich UBS, Benda J, Gardella E, Lerche H, Møller RS

Gut-based manipulations spur hippocampal mitochondrial bioenergetics in a model of pediatric epilepsy.
Mu C, Tompkins TA, Rho JM, Scantlebury MH, Shearer J

Targeted gut microbiota manipulation attenuates seizures in a model of infantile spasms syndrome.
Mu C, Nikpoor N, Tompkins TA, Choudhary A, Wang M, Marks WN, Rho JM, Scantlebury MH, Shearer J

Selective Probiotic Treatment Positively Modulates the Microbiota-Gut-Brain Axis in the BTBR Mouse Model of Autism.
Pochakom A, Mu C, Rho JM, Tompkins TA, Mayengbam S, Shearer J

The metabolic basis of epilepsy.
Rho JM, Boison D

Addition of Prebiotics to the Ketogenic Diet Improves Metabolic Profile but Does Not Affect Seizures in a Rodent Model of Infantile Spasms Syndrome.
Mu C, Pochakom A, Reimer RA, Choudhary A, Wang M, Rho JM, Scantlebury MH, Shearer J

Abnormal oxidative metabolism in the cuprizone mouse model of demyelination: An in vivo NIRS-MRI study.
Hashem M, Shafqat Q, Wu Y, Rho JM, Dunn JF

Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy.
Mu C, Nikpoor N, Tompkins TA, Rho JM, Scantlebury MH, Shearer J

Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms.
Mu C, Choudhary A, Mayengbam S, Barrett KT, Rho JM, Shearer J, Scantlebury MH

Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats.
Baglot SL, Hume C, Petrie GN, Aukema RJ, Lightfoot SHM, Grace LM, Zhou R, Parker L, Rho JM, Borgland SL, McLaughlin RJ, Brechenmacher L, Hill MN

Gene-Targeted Therapies in Pediatric Neurology: Challenges and Opportunities in Diagnosis and Delivery.
Shellhaas RA, deVeber G, Bonkowsky JL, Child Neurology Society Research Committee

A ketogenic diet affects brain volume and metabolome in juvenile mice.
Mayengbam S, Ellegood J, Kesler M, Reimer RA, Shearer J, Murari K, Rho JM, Lerch JP, Cheng N

Prebiotic, Probiotic, and Synbiotic Consumption Alter Behavioral Variables and Intestinal Permeability and Microbiota in BTBR Mice.
Nettleton JE, Klancic T, Schick A, Choo AC, Cheng N, Shearer J, Borgland SL, Rho JM, Reimer RA

The link between brain acidosis, breathing and seizures: a novel mechanism of action for the ketogenic diet in a model of infantile spasms.
Choudhary A, Mu C, Barrett KT, Charkhand B, Williams-Dyjur C, Marks WN, Shearer J, Rho JM, Scantlebury MH

Metabolism-based therapies for epilepsy: new directions for future cures.
Cervenka M, Pascual JM, Rho JM, Thiele E, Yellen G, Whittemore V, Hartman AL

Ketogenic diet-mediated seizure reduction preserves CA1 cell numbers in epileptic Kcna1-null mice: An unbiased stereological assessment.
Simeone KA, Wilke JC, Matthews SA, Simeone TA, Rho JM

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.