Research and Clinical Trials
The Division’s research programs range from basic science projects on the effect of disordered respiration, hypoxia (low oxygen) and hypercapnia (elevated carbon dioxide in the blood) on cell function and fate in vital organs, to cutting-edge basic and clinical research on cystic fibrosis. This includes a research collaboration with the laboratory of Rob Knight, Ph.D., (UC San Diego) to investigate the role of the microbiome in patients with cystic fibrosis and chronic airway diseases. Faculty scholars provide research training and mentorship to future investigators.
Understanding the molecular, cellular and genetic mechanisms that contribute to low oxygen tolerance or susceptibility will have a major impact on treatments of central nervous system and cardiorespiratory diseases and events, including stroke, heart attack, obstructive sleep apnea and pulmonary hypertension
A laboratory study by Gabriel G. Haddad, M.D., physician-in-chief and chief scientific officer at Rady Children’s Hospital-San Diego and chair of the Department of Pediatrics at the UC San Diego School of Medicine, working with researchers at UC San Diego, has identified a genetic mechanism involved in low oxygen tolerance, suggesting that a gene could be targeted to treat sea-level diseases that stem from lack of oxygen. Read more.
In another study, Dr. Haddad and a research team decoded the genetic basis of chronic mountain sickness (CMS), or Monge’s disease. The study provides important information that validates the genetic basis of adaptation to high altitudes and provides potential targets for CMS treatment. Read more.
For detailed information on the research activities of our members, visit the UC San Diego Department of Pediatrics website.