Fred Levine, M.D.


Metabolic and Mitochondrial Medicine


3020 Children's Way
MC 5110
San Diego, CA 92123


Metabolic and Mitochondrial Medicine


Rady Children's Specialists of San Diego

Medical Group / IPA

Rady Children's Specialists


Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β-cell, regeneration.
Chung CH, Miller A, Panopoulos A, Hao E, Margolis R, Terskikh A, Levine F

Induction of β-cell replication by a synthetic HNF4α antagonist.
Lee SH, Piran R, Keinan E, Pinkerton A, Levine F

Efficient β-cell regeneration by a combination of neogenesis and replication following β-cell ablation and reversal of pancreatic duct ligation.
Hao E, Lee SH, Levine F

Identification of alverine and benfluorex as HNF4α activators.
Lee SH, Athavankar S, Cohen T, Piran R, Kiselyuk A, Levine F

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.
Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F

T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion.
Tyrberg B, Miles P, Azizian KT, Denzel MS, Nieves ML, Monosov EZ, Levine F, Ranscht B

Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells.
Lee SH, Hao E, Levine F, Itkin-Ansari P

β-Cell replication and islet neogenesis following partial pancreatectomy.
Lee SH, Hao E, Levine F

The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma.
Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P

CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells.
Lee SH, Itkin-Ansari P, Levine F

Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration.
Chung CH, Levine F

Pancreatic β-cell neogenesis by direct conversion from mature α-cells.
Chung CH, Hao E, Piran R, Keinan E, Levine F

Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen.
Kiselyuk A, Farber-Katz S, Cohen T, Lee SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F

Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells.
Zhang SS, Hao E, Yu J, Liu W, Wang J, Levine F, Feng GS

Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.
Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK

Islet specific Wnt activation in human type II diabetes.
Lee SH, Demeterco C, Geron I, Abrahamsson A, Levine F, Itkin-Ansari P

beta-cell Regeneration: neogenesis, replication or both?
Levine F, Itkin-Ansari P

HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion.
Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F

Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells.
Katkov II, Kim MS, Bajpai R, Altman YS, Mercola M, Loring JF, Terskikh AV, Snyder EY, Levine F

Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.
Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F

Telomere-independent cellular senescence in human fetal cardiomyocytes.
Ball AJ, Levine F

Chronic treatment of mitochondrial disease patients with dichloroacetate.
Barshop BA, Naviaux RK, McGowan KA, Levine F, Nyhan WL, Loupis-Geller A, Haas RH

No pancreatic endocrine stem cells?
Levine F, Mercola M

Sources of beta-cells for human cell-based therapies for diabetes.
Itkin-Ansari P, Levine F

Prediction of the glass transition temperature of water solutions: comparison of different models.
Katkov II, Levine F

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

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