Richard Haas, M.D.


3020 Children's Way
MC 5009
San Diego, CA 92123




Rady Children's Specialists of San Diego

Medical Group / IPA

Rady Children's Specialists

Medical School

University of London


University College - London


Hammersmith Hospital, London, University of Colorado School of Medicine

Board Certifications





Dr. Richard Haas is a neurologist at Rady Children's Hospital-San Diego as well as director of the Mitochondrial Disease Laboratory and a professor at UC San Diego.

Dr. Haas obtained his medical degree from the University of London. He completed residencies in internal medicine, neurology and pediatrics, followed by a fellowship in pediatric neurology at the University of Colorado.

Dr. Haas specializes in mitochondrial disorders and the relationship between metabolic defects and serious neurological diseases. He and Robert Naviaux, MD, PhD, identified mutations in mitochondrial polymerase activity as the cause of Alper's syndrome, a devastating childhood mitochondrial disease. He also recently collaborated with researchers at UC Irvine to study mitochondrial dysfunction in autism.

In 1994, Dr. Haas established what is now the Mitochondrial and Metabolic Disease Center and laboratory at UC San Diego as a facility dedicated to the research and clinical evaluation of mitochondrial disorders. His attempt to merge research and patient care has been a hallmark of his career and has created a referral base of both domestic and international patients.

Dr. Haas's clinical interests include neurometabolic disease, general child neurology, Rett Syndrome, neuromuscular disease and neonatal neurology. He serves on the editorial board of the European Journal of Pediatric Neurology and is a member of the scientific advisory board of the United Mitochondrial Disease Foundation. He reviews various journals, including Proceedings of the National Academy of Sciences, Journal of Pediatric Neurology, Annals of Neurology and Molecular Genetics and Metabolism.

Dr. Haas is currently principal investigator of two clinical trials at Rady Children's. He is evaluating the safety of eteplirsen for Duchenne muscular dystrophy and, along with Drs. Mark Nespeca, Sonya Wang and Jeffrey Gold, is studying the efficacy of an intravenous drug on neonatal seizures. As director and principal investigator for the North American Mitochondrial Disease Consortium training fellowship, he aims to train clinician scientists who will be able to bring promising new treatments for mitochondrial disease into the clinical arena.


Platelet Mitochondrial Activity and Pesticide Exposure in Early Parkinson's Disease
Bronstein JM, Paul K, Yang L, Haas RH, SHults CW, Le T, Ritz B

Assessing Bioenergetic Compromise in Autism Spectrum Disorder with 31P Magnetic Resonance Spectroscopy: Preliminary Report
Golomb BA, Erickson LC, Scott-Van Zeeland AA, Koperski S, Haas RH, Wallace DC, Naviaux RK, Lincoln AJ, Reiner GE, Hamilton G

Orthostatic Tremor, Progressive External Ophthalmoplegia, and Twinkle
Milone M, Klassen BT, Landsverk ML, Haas RH, Wong LJ

Practice Patterns of Mitochondrial Disease Physicians in North America. Part 1: Diagnostic and Clinical Challenges
Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R; Mitochondrial Medicine Society Clinical Directors Working Group; MMS Clinical Director's Work Group, Anselm I, Collins A, Cohen BH, DeBrosse SD, Dimmock D, Falk MJ, Ganesh J, Greene C, Gropman AL, Haas R, Kahler SG, Kamholz J, Kendall F, Korson MS, Mattman A, Milone M, Niyazov D, Pearl PL, Reimschisel T, Salvarinova-Zivkovic R, Sims K, Tarnopolsky M, Tsao CY, van Hove J, Walsh L, Wolfe LA

Automated Methods for the Analysis of Skeletal Muscle Fiber Size and Metabolic Type
Kostrominoya TY, Reiner DS, Haas RH, Ingermanson R, McDonough PM

Primary Respiratory Chain Disease Causes Tissue-Specific Dysregulation of the Global Transcriptome and Nutrient-Sensing Signal Network
Zhang Z, Tsukikawa M, Peng M, Polyak E, Nakamaru-Ogiso E, Ostrovsky J, McCormack S, Place E, Clarke C, Reiner G, McCormick E, Rappaport E, Haas R, Baur JA, Falk MJ

Heteroplasmic Mutations of the Mitochondrial Genome Cause Paradoxical Effects on Mitochondrial Functions
Zhang C, Huang VH, Simon M, Sharma LK, Fan W, Haas R, Wallace DC, Bai Y, Huang T

Mitochondrial and Ion Channel Gene Alterations in Autism
Smith M, Flodman PL, Gargus JJ, Simon MT, Verrell K, Haas R, Reiner GE, Naviaux R, Osann K, Spence MA, Wallace DC

Effects of Endotracheal Intubation and Surfactant on a 3-Channel Neonatal Electroencephalogram
Shangle CE, Haas RH, Vaida F, Rich WD, Finer NN

A Seven-Day Study of the Pharmacokinetics of Intravenous Levetiracetam in Neonates: Marked Changes in Pharmacokinetics Occur During the First Week of Life
Sharpe CM, Capparelli EV, Mower A, Farrell MJ, Soldin SJ, Haas RH

Quality Improvement of Mitochondrial Respiratory Chain Complex Enzyme Assays Using Caenorhabditis Elegans
Chen X, Thorburn DR, Wong LJ, Vladutiu GD, Haas RH, Le T, Hoppel C, Sedensky M, Morgan P, Hahn SH

Fibroblast Immuno-Diagnosis of Cytochrome Oxidase (COX) Deficiency in Mitochondrial Disease
Du A, Naviaux RK, Le T, Xu C, Sommer SS, Haas RH

Platelet Mitochondrial Complex I and I+III Activities Do Not Correlate with Cerebral Mitochondrial Oxidative Metabolism
Powers WJ, Haas RH, Le T, Videen TO, Markham J, Perlmutter JS

Autism and Mitochondrial Disease
Haas RH

A Modern Approach to the Treatment of Mitochondrial Disease
Parikh S, Saneto R, Falk MJ, Anselm I, Cohen BH, Haas R, Medicine Society TM

Pitfalls in the Denaturing High-Performance Liquid Chromatography Analysis of Mitochondrial DNA Mutation
Lim KS, Naviaux RK, Wong S, Haas RH

The In-Depth Evaluation of Suspected Mitochondrial Disease
Mitochondrial Medicine Society's Committee on Diagnosis, Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darrin N, Wong LJ, Cohen BH, Naviaux RK

Mitochondrial Disease: A Practical Approach for Primary Care Physicians
Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darrin N, Cohen BH

Quantitative Mitochondrial DNA Mutation Analysis by Denaturing HPLC
Lim KS, Naviaux RK, Haas RH

Chronic Treatment of Mitochondrial Disease Patients with Dichloroacetate
Barshop BA, Naviaux RK, McGowan KA, Levine F, Nyhan WL, Loupis-Geller A, Haas RH

Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline
Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M; Parkinson Study Group

Nerve Conduction Changes in Patients with Mitochondrial Diseases Treated with Dichloroacetate
Spruijt L, Naviaux RK, McGowan KA, Nyhan WL, Sheean G, Haas RH, Barshop BA

Mitochondrial DNA Polymerase Gamma Deficiency and mtDNA Depletion in a Child with Alpers' Syndrome
Naviaux RK, Nyhan WL, Barshop BA, Poulton J, Markusiic D, Karpinski NC, Haas RH

Low Platelet Mitochondrial Complex I and Complex II/III Activity in Early Untreated Parkinson's Disease
Haas RH, Nasirian F, Nakano K, Ward D, Pay M, Hill R, Shults CW

Pyruvate Dehydrogenase Activity in Osmotically Shocked Rat Brain Mitochondria: Stimulation by Oxaloacetate
Haas RH, Thompson G, Morris b, Conright K, Andrews T

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