Kincheon Bryan Li, M.D., Ph.D

Bio

Dr. Li is a pediatric hematologist/oncologist and physician-scientist focusing on aggressive childhood brain tumors at Rady Children’s Hospital and UC San Diego.

He completed most of his medical and research training at the University of Toronto and the Hospital for Sick Children, including medical school, pediatrics residency, pediatric hematology/oncology fellowship, and a PhD under advisor Dr. Annie Huang. He was among the first scientists to define the now World Health Organization-recognized molecular subgroups of pineoblastoma, a rare but highly lethal brain tumor arising in young children. He later completed a pediatric neuro-oncology fellowship at Memorial Sloan Kettering Cancer Center in New York, before joining the Icahn School of Medicine at Mount Sinai as an Assistant Professor of Pediatrics.

Under the mentorship of Dr. Praveen Raju beginning at Sinai, and continuing at Rady’s and UCSD, he has been studying how to circumvent the blood-brain barrier to improve therapies for highly aggressive childhood brain tumors like diffuse intrinsic pontine glioma (DIPG). Specifically, he has been developing novel P-selectin targeting nanomedicines to package anti-cancer therapeutics, enhancing their delivery into the tumor space while sparing normal brain tissue to reduce side-effects.

Clinically, he primarily works with the Neuro-Oncology and Solid Tumor programs in the outpatient clinic and inpatient unit.

Publications

Phase 3 randomized trial [ACNS0334] of high-dose methotrexate for young children with high-risk embryonal brain tumors: A report from the Children’s Oncology Group.
Mazewski C, Leary SES, Kang G, Li BK, … Fouladi M, Huang A.

A population-based analysis of the molecular landscape of gliomas in adolescents and young adults reveals insights into gliomagenesis.
Bennett J, Levine A, … Li BK, … Tabori U, Hawkins C.

SNO-EANO-EURACAN consensus review on the diagnosis and management of pineal parenchymal tumors.
Liu APY, Li BK, Vasiljevic A, … Wen PY, van den Bent MJ, Huang A.

Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome.
Kolodziejczak AS, Guerrini-Rousseau L, … Li BK, … Milde T.

Recurrent TRAK1::RAF1 fusions in pediatric low-grade gliomas.
Benhamida JK, Harmsen HJ, Ma D, William CM, Li BK, … Rosenblum MK, Bale TA.

YAP1-MAML2 fusion in a pediatric NF2-wildtype brainstem schwannoma.
Karajannis M, Li BK, Souweidane MM, … Bale TA, Rosenblum MK.

Infantile suprasellar tumor diagnosed as a pineoblastoma RB1 subgroup and treatment challenges: a pediatric SNO molecular tumor board.
Rubens JA, Erker C, Lindsay H, Ho B, Li BK, Bouffet E, … Huang A, Packer R.

Pineoblastoma: A pooled outcome study of North American and Australian therapeutic data.
Hansford JR, Huang J, Endersby R, Dodgshun AJ, Li BK, … Gottardo NG.

Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.
Liu APY*, Li BK*, Gudenas B*, Pfaff E*, … Northcott P, Jones DT, Huang A (*co-first authors).

WNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup?
Liu APY, Priesterbach-Ackley LP, Orr BA, Li BK, … Gajjar A.

Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.
Chung P, Gendoo D, Ghanbari-Azarnier R, Liu J, Jiang Z, Tsui J, Li BK, … Zacksenhaus E.

Pediatric embryonal brain tumors in the molecular era.
Li BK, Al-Karmi S, Huang A, Bouffet E.

Pineoblastoma segregates into molecular subgroups with distinct clinicopathologic features: A Rare Brain Tumor Consortium study.
Li BK, Vasiljevic A, … Jouvet A, Huang A.

Molecular classification and management of rare pediatric embryonal brain tumors.
Sin-Chan P*, Li BK*, Ho B, Fonseca A, Huang A (*co-first authors).

Surveillance imaging and radiation exposure in the detection of relapsed neuroblastoma.
Owens C*, Li BK*, Thomas KE, Irwin MS (*co-first authors).

Chemotherapy induces NEDP1-mediated destabilization of Mdm2.
Watson IR, Li BK, Roche O, Blanch A, Ohh M, Irwin MS.

See the full listing of this physician's publications on PubMed a service of the National Library of Medicine.