Locations

San Diego County

3020 Children's Way
MC 5065
San Diego, CA 92123

Specialty

Critical Care

Organization

UC San Diego Health

Medical Group / IPA

UC San Diego Health

Medical School

University of California - San Diego

Internship

UC San Diego

Residency

UC San Diego

Fellowship

UC San Diego

Board Certifications

Pediatrics

Gender

F

Bio

Dr. Nicole Coufal is a board-certified pediatrician and pediatric intensivist at Rady Children's Hospital-San Diego and an assistant professor at UC San Diego School of Medicine.

She received her medical and doctoral degree in neurosciences at UC San Diego. Thereafter Dr. Coufal continued her training in pediatrics and pediatric critical care at UC San Diego as well as a postdoctoral fellowship at the Salk Institute for Biological Studies.

The Coufal lab's primary research interests are to understand the molecular and cellular mechanisms underlying the development and regulation of microglia, the brain's resident macrophage. Current projects focus on understanding how microglia are affected by their environment and how they become dysregulated in the setting of neuroinflammatory disease. To understand and model microglial biology, Dr. Coufal utilizes induced pluripotent stem cells and genome-wide approaches to identify transcriptional and epigenetic mechanisms. By improving modeling of genetic and idiopathic neuroinflammatory disease she hopes to ultimately improve the understanding and treatment of critical pediatric neuroinflammatory disease.

Dr. Coufal is a fellow of the American Academy of Pediatrics, a member of the Society for Critical Care Medicine and a member of the Society for Neuroscience.

Publications

Use of Metagenomic Next-Generation Sequencing to Identify Pathogens in Pediatric Osteoarticular Infections.
Ramchandar N, Burns J, Coufal NG, Pennock A, Briggs B, Stinnett R, Bradley J, Arnold J, Liu GY, Pring M, Upasani VV, Rickert K, Dimmock D, Chiu C, Farnaes L, Cannavino C

Clinical application of cell-free next-generation sequencing for infectious diseases at a tertiary children's hospital.
Wilke J, Ramchandar N, Cannavino C, Pong A, Tremoulet A, Padua LT, Harvey H, Foley J, Farnaes L, Coufal NG

Metagenomic Next-Generation Sequencing for Pathogen Detection and Transcriptomic Analysis in Pediatric Central Nervous System Infections.
Ramchandar N, Coufal NG, Warden AS, Briggs B, Schwarz T, Stinnett R, Xie H, Schlaberg R, Foley J, Clarke C, Waldeman B, Enriquez C, Osborne S, Arrieta A, Salyakina D, Janvier M, Sendi P, Totapally BR, Dimmock D, Farnaes L

Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients: a case series and review of the literature.
Masso-Silva JA, Moshensky A, Lam MTY, Odish M, Patel A, Xu L, Hansen E, Trescott S, Nguyen C, Kim R, Perofsky K, Perera S, Ma L, Pham J, Rolfsen M, Olay J, Shin J, Dan JM, Abbott R, Ramirez S, Alexander TH, Lin GY, Fuentes AL, Advani I, Gunge D, Pretorius V, Malhotra A, Sun X, Duran J, Hepokoski M, Crotty S, Coufal NG, Meier A, Alexander LEC

The Utility of Infectious and Neurodiagnostic Testing in Children With Complex Febrile Seizures Requiring Mechanical Ventilation.
Yang JH, Villegas R, Khanna S, Kaswick J, Coufal NG, Crawford J, Harvey H

Contemporary management of pediatric open skull fractures: a multicenter pediatric trauma center study.
McFall C, Beier AD, Hayward K, Alberto EC, Burd RS, Farr BJ, Mooney DP, Gee K, Upperman JS, Escobar MA, Coufal NG, Harvey HA, Gollin G

Use of Plasma Metagenomic Next-generation Sequencing for Pathogen Identification in Pediatric Endocarditis.
To RK, Ramchandar N, Gupta A, Pong A, Cannavino C, Foley J, Farnaes L, Coufal NG

Metagenomic sequencing and evaluation of the host response in the pediatric aerodigestive population.
Gatcliffe C, Rao A, Brigger M, Dimmock D, Hansen C, Montgomery J, Schlaberg R, Coufal NG, Farnaes L

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.
Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M

Rapid Whole Genome Sequencing Has Clinical Utility in Children in the PICU.
Sanford EF, Clark MM, Farnaes L, Williams MR, Perry JC, Ingulli EG, Sweeney NM, Doshi A, Gold JJ, Briggs B, Bainbridge MN, Feddock M, Watkins K, Chowdhury S, Nahas SA, Dimmock DP, Kingsmore SF, Coufal NG, RCIGM Investigators.

Neonatal diabetes mellitus due to a novel variant in the INS gene.
Laurenzano SE, McFall C, Nguyen L, Savla D, Coufal NG, Wright MS, Tokita M, Dimmock D, Kingsmore SF, Newfield RS

Vaccine Strain Varicella Infection in an Infant With Previously Undiagnosed Perinatal Human Immunodeficiency Type-1 Infection.
Farnaes L, Coufal NG, Spector SA

Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management.
Farnaes L, Wilke J, Ryan Loker K, Bradley JS, Cannavino CR, Hong DK, Pong A, Foley J, Coufal NG

Paediatric pulmonary hypertension caused by an ACVRL1 mutation presenting as Ortner syndrome.
Alsheikh B, Aljohani O, Coufal NG

Rapid whole-genome sequencing identifies a novel AIRE variant associated with autoimmune polyendocrine syndrome type 1.
Sanford E, Watkins K, Nahas S, Gottschalk M, Coufal NG, Farnaes L, Dimmock D, Kingsmore SF, RCIGM Investigators.

Encephalitis and Thalamic Injury From Neuroinvasive West Nile Virus in Children on Treatment for Acute Lymphoblastic Leukemia.
Farnaes L, Schiff D, McElroy AK, Coufal NG, Crawford JR, Cannavino C

An environment-dependent transcriptional network specifies human microglia identity.
Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK

Primary cilia in the developing and mature brain.
Guemez-Gamboa A, Coufal NG, Gleeson JG

CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration.
Schaffer AE, Eggens VR, Caglayan AO, Reuter MS, Scott E, Coufal NG, Silhavy JL, Xue Y, Kayserili H, Yasuno K, Rosti RO, Abdellateef M, Caglar C, Kasher PR, Cazemier JL, Weterman MA, Cantagrel V, Cai N, Zweier C, Altunoglu U, Satkin NB, Aktar F, Tuysuz B, Yalcinkaya C, Caksen H, Bilguvar K, Fu XD, Trotta CR, Gabriel S, Reis A, Gunel M, Baas F, Gleeson JG

Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis.
Farnaes L, Coufal NG, Kauffman CA, Rheingold AL, DiPasquale AG, Jensen PR, Fenical W

Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.
Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage FH

Gastric trichobezoar causing intermittent small bowel obstruction: report of a case and review of the literature.
Coufal NG, Kansagra AP, Doucet J, Lee J, Coimbra R, Bansal V

L1 retrotransposition in neurons is modulated by MeCP2.
Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage FH

LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?
Singer T, McConnell MJ, Marchetto MC, Coufal NG, Gage FH

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.

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