Nicole Coufal, M.D., Ph.D.

Locations

3020 Children's Way
MC 5065
San Diego, CA 92123

Specialty

Critical Care

Organization

UC San Diego Health

Medical Group / IPA

UC San Diego Health

Medical School

University of California - San Diego

Internship

UC San Diego

Residency

UC San Diego

Fellowship

UC San Diego

Board Certifications

Pediatrics

Gender

F

Bio

Dr. Nicole Coufal is a board-certified pediatrician and pediatric intensivist at Rady Children's Hospital-San Diego and an assistant professor at UC San Diego School of Medicine.

She received her medical and doctoral degree in neurosciences at UC San Diego. Thereafter Dr. Coufal continued her training in pediatrics and pediatric critical care at UC San Diego as well as a postdoctoral fellowship at the Salk Institute for Biological Studies.

The Coufal lab's primary research interests are to understand the molecular and cellular mechanisms underlying the development and regulation of microglia, the brain's resident macrophage. Current projects focus on understanding how microglia are affected by their environment and how they become dysregulated in the setting of neuroinflammatory disease. To understand and model microglial biology, Dr. Coufal utilizes induced pluripotent stem cells and genome-wide approaches to identify transcriptional and epigenetic mechanisms. By improving modeling of genetic and idiopathic neuroinflammatory disease she hopes to ultimately improve the understanding and treatment of critical pediatric neuroinflammatory disease.

Dr. Coufal is a fellow of the American Academy of Pediatrics, a member of the Society for Critical Care Medicine and a member of the Society for Neuroscience.

Publications

Paediatric pulmonary hypertension caused by an ACVRL1 mutation presenting as Ortner syndrome.
Alsheikh B, Aljohani O, Coufal NG

Vaccine Strain Varicella Infection in an Infant with Previously Undiagnosed Perinatal Human Immunodeficiency Type-1 Infection.
Farnaes L, Coufal N, Spector SA

Rapid whole-genome sequencing identifies a novel <i>AIRE</i> variant associated with autoimmune polyendocrine syndrome type 1.
Sanford E, Watkins K, Nahas S, Gottschalk M, Coufal NG, Farnaes L, Dimmock D, Kingsmore SF, RCIGM Investigators.

Encephalitis and Thalamic Injury From Neuroinvasive West Nile Virus in Children on Treatment for Acute Lymphoblastic Leukemia.
Farnaes L, Schiff D, McElroy AK, Coufal NG, Crawford JR, Cannavino C

An environment-dependent transcriptional network specifies human microglia identity.
Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK

Primary cilia in the developing and mature brain.
Guemez-Gamboa A, Coufal NG, Gleeson JG

CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration.
Schaffer AE, Eggens VR, Caglayan AO, Reuter MS, Scott E, Coufal NG, Silhavy JL, Xue Y, Kayserili H, Yasuno K, Rosti RO, Abdellateef M, Caglar C, Kasher PR, Cazemier JL, Weterman MA, Cantagrel V, Cai N, Zweier C, Altunoglu U, Satkin NB, Aktar F, Tuysuz B, Yalcinkaya C, Caksen H, Bilguvar K, Fu XD, Trotta CR, Gabriel S, Reis A, Gunel M, Baas F, Gleeson JG

Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis.
Farnaes L, Coufal NG, Kauffman CA, Rheingold AL, DiPasquale AG, Jensen PR, Fenical W

Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.
Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage FH

Gastric trichobezoar causing intermittent small bowel obstruction: report of a case and review of the literature.
Coufal NG, Kansagra AP, Doucet J, Lee J, Coimbra R, Bansal V

L1 retrotransposition in neurons is modulated by MeCP2.
Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage FH

LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?
Singer T, McConnell MJ, Marchetto MC, Coufal NG, Gage FH

L1 retrotransposition in human neural progenitor cells.
Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O'Shea KS, Moran JV, Gage FH

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells.
Yeo GW, Coufal NG, Liang TY, Peng GE, Fu XD, Gage FH

Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells.
Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri AR, Carson C, Gage FH

Alternative splicing events identified in human embryonic stem cells and neural progenitors.
Yeo GW, Xu X, Liang TY, Muotri AR, Carson CT, Coufal NG, Gage FH

The necessary junk: new functions for transposable elements.
Muotri AR, Marchetto MC, Coufal NG, Gage FH

LINE-1 retrotransposition in human embryonic stem cells.
Garcia-Perez JL, Marchetto MC, Muotri AR, Coufal NG, Gage FH, O'Shea KS, Moran JV

Regulatable acetylcholine-producing fibroblasts enhance cognitive performance.
Pizzo DP, Coufal NG, Lortie MJ, Gage FH, Thal LJ

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.
Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E

Long-term production of choline acetyltransferase in the CNS after transplantation of fibroblasts modified with a regulatable vector.
Pizzo DP, Paban V, Coufal NG, Gage FH, Thal LJ

Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency.
Brandon EP, Mellott T, Pizzo DP, Coufal N, D'Amour KA, Gobeske K, Lortie M, López-Coviella I, Berse B, Thal LJ, Gage FH, Blusztajn JK

Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice.
Rocha BA, Goulding EH, O'Dell LE, Mead AN, Coufal NG, Parsons LH, Tecott LH

See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.

PubMed is a third-party website and not affiliated with Rady Children's Hospital-San Diego.

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