3020 Children's Way
San Diego, CA 92123
UC San Diego Health
UC San Diego Health
University of California - San Diego
UC San Diego
UC San Diego
UC San Diego
Dr. Nicole Coufal is a board-certified pediatrician and pediatric intensivist at Rady Children's Hospital-San Diego and an assistant professor at UC San Diego School of Medicine.
She received her medical and doctoral degree in neurosciences at UC San Diego. Thereafter Dr. Coufal continued her training in pediatrics and pediatric critical care at UC San Diego as well as a postdoctoral fellowship at the Salk Institute for Biological Studies.
The Coufal lab's primary research interests are to understand the molecular and cellular mechanisms underlying the development and regulation of microglia, the brain's resident macrophage. Current projects focus on understanding how microglia are affected by their environment and how they become dysregulated in the setting of neuroinflammatory disease. To understand and model microglial biology, Dr. Coufal utilizes induced pluripotent stem cells and genome-wide approaches to identify transcriptional and epigenetic mechanisms. By improving modeling of genetic and idiopathic neuroinflammatory disease she hopes to ultimately improve the understanding and treatment of critical pediatric neuroinflammatory disease.
Dr. Coufal is a fellow of the American Academy of Pediatrics, a member of the Society for Critical Care Medicine and a member of the Society for Neuroscience.
Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.
Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK
Development of a Chimeric Model to Study and Manipulate Human Microglia InÂ Vivo.
Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M
Rapid Whole Genome Sequencing Has Clinical Utility in Children in the PICU.
Sanford EF, Clark MM, Farnaes L, Williams MR, Perry JC, Ingulli EG, Sweeney NM, Doshi A, Gold JJ, Briggs B, Bainbridge MN, Feddock M, Watkins K, Chowdhury S, Nahas SA, Dimmock DP, Kingsmore SF, Coufal NG, RCIGM Investigators.
Neonatal diabetes mellitus due to a novel variant in the INS gene.
Laurenzano SE, McFall C, Nguyen L, Savla D, Coufal NG, Wright MS, Tokita M, Dimmock D, Kingsmore SF, Newfield RS
Vaccine Strain Varicella Infection in an Infant With Previously Undiagnosed Perinatal Human Immunodeficiency Type-1 Infection.
Farnaes L, Coufal NG, Spector SA
Community-acquired pneumonia in children: cell-free plasma sequencing for diagnosis and management.
Farnaes L, Wilke J, Ryan Loker K, Bradley JS, Cannavino CR, Hong DK, Pong A, Foley J, Coufal NG
Paediatric pulmonary hypertension caused by an ACVRL1 mutation presenting as Ortner syndrome.
Alsheikh B, Aljohani O, Coufal NG
Rapid whole-genome sequencing identifies a novel AIRE variant associated with autoimmune polyendocrine syndrome type 1.
Sanford E, Watkins K, Nahas S, Gottschalk M, Coufal NG, Farnaes L, Dimmock D, Kingsmore SF, RCIGM Investigators.
Encephalitis and Thalamic Injury From Neuroinvasive West Nile Virus in Children on Treatment for Acute Lymphoblastic Leukemia.
Farnaes L, Schiff D, McElroy AK, Coufal NG, Crawford JR, Cannavino C
An environment-dependent transcriptional network specifies human microglia identity.
Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK
Primary cilia in the developing and mature brain.
Guemez-Gamboa A, Coufal NG, Gleeson JG
CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration.
Schaffer AE, Eggens VR, Caglayan AO, Reuter MS, Scott E, Coufal NG, Silhavy JL, Xue Y, Kayserili H, Yasuno K, Rosti RO, Abdellateef M, Caglar C, Kasher PR, Cazemier JL, Weterman MA, Cantagrel V, Cai N, Zweier C, Altunoglu U, Satkin NB, Aktar F, Tuysuz B, Yalcinkaya C, Caksen H, Bilguvar K, Fu XD, Trotta CR, Gabriel S, Reis A, Gunel M, Baas F, Gleeson JG
Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis.
Farnaes L, Coufal NG, Kauffman CA, Rheingold AL, DiPasquale AG, Jensen PR, Fenical W
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.
Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage FH
Gastric trichobezoar causing intermittent small bowel obstruction: report of a case and review of the literature.
Coufal NG, Kansagra AP, Doucet J, Lee J, Coimbra R, Bansal V
L1 retrotransposition in neurons is modulated by MeCP2.
Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage FH
LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?
Singer T, McConnell MJ, Marchetto MC, Coufal NG, Gage FH
L1 retrotransposition in human neural progenitor cells.
Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O'Shea KS, Moran JV, Gage FH
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells.
Yeo GW, Coufal NG, Liang TY, Peng GE, Fu XD, Gage FH
Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells.
Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri AR, Carson C, Gage FH
Alternative splicing events identified in human embryonic stem cells and neural progenitors.
Yeo GW, Xu X, Liang TY, Muotri AR, Carson CT, Coufal NG, Gage FH
The necessary junk: new functions for transposable elements.
Muotri AR, Marchetto MC, Coufal NG, Gage FH
LINE-1 retrotransposition in human embryonic stem cells.
Garcia-Perez JL, Marchetto MC, Muotri AR, Coufal NG, Gage FH, O'Shea KS, Moran JV
Regulatable acetylcholine-producing fibroblasts enhance cognitive performance.
Pizzo DP, Coufal NG, Lortie MJ, Gage FH, Thal LJ
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.
Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E
See the full listing of this physician's publications on PubMed, a service of the National Library of Medicine.
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