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Lab Test Dictionary

Cryoglobulin Screen with Reflex to Cryoglobulin Profile, Serum (37358)


Cryocrit; Electrophoresis; Immunodiffusion (ID);Immunofixation (IF); Rate Nephelometry

Specimen Type


Performing Lab

Quest Diagnostics San Juan Capistrano

Epic ID

Other Reference Test

Lab Test Days


Standard TAT

5-7 Days

Collection Information

Specimen Required

7-20 mL Blood

Container Type

Red Top (No Additive)

Collection Instructions

Overnight fasting is required. Avoid hemolysis. After collection, place specimen in a heat pack or warm bath and deliver to lab asap.

Processing Information - Lab Use Only

Transport Temperature


Specimen Stability

Room Temp=72 Hours; Refrigerated=Unacceptable; Frozen=Unacceptable

Rejection Criteria

Gross hemolysis; Lipemia; Icteric; Serum separator tube (SST)

Test Volume Required

10 mL Incubated Serum

Minimum Test Volume

3.5 mL Incubated Serum

Processing Instructions

Allow serum to clot for ONE HOUR in 37 C water bath, oven, incubator, or heat pack. After clotting, centrifuge the specimen for 10 minutes at 3000 rpm utilizing on of the 3 options below: 1) In a "warm" centrifuge at 37 C; 2) In a bech-top centrifuge placed in a "warm room" at 37 C; 3) At room temp, in a bench-top centrifuge pre-warmed by running it for 10 minutes at 2000 rpm. After centrifuging, decant serum into a screw-cap vial. Transport at room temp. Avoid hemolysis. NOTE: No other tests can be added to the tube; cryocrit and cryoglobulin evaluation only.

Included Tests

If cryoglobulin is present (positive), it is identified. Positives are semi-quantitated (as % cryoglobulin) by cryocrit.When Cryoglobulin Screen is positive, Cryoglobulin Profile (Cryocrit Immunofixation, Cryocrit Immunodiffusion and Rheumatoid Factor) will be performed.

CPT Codes

82595; 86334, 86329; 86431 (not genetic)