Recurrent Fever Disorders Clinic

Children with rare, autoinflammatory and recurrent noninfectious fever disorders are evaluated at Rady Children’s Hospital-San Diego, tested for inflammatory markers and educated on their disease and potential therapeutic interventions to create an integrated care plan.

Our team consists of pediatric allergists/immunologists Lori Broderick, M.D., Ph.D., and Hal M. Hoffman, M.D.  Participation in research is offered to patients who are interested and meet the appropriate criteria.

About Autoinflammation and Recurrent Fever Disorders

Autoinflammatory disorders are recently recognized syndromes believed to be due to overactive immune systems, rather than an immune deficiency. These disorders include periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome, familial Mediterranean fever (FMF), the cryopyrinopathies (cryopyrin-associated periodic syndromes, or CAPS), tumor necrosis factor receptor-associated periodic syndrome (TRAPS) and hyper-IgD syndrome/mevalonic kinase deficiency (HIDS/MKD), among others.

Five Signs of Autoinflammation:

  • Recurrent unexplained non-infectious episodes (>3) of fever (>101° F)
  • Each episode has a predictable pattern or characteristic course
  • Episodes characterized by specific symptoms including non-itchy rash, extremity/joint pain, severe abdominal pain, and/or conjunctivitis and absence of upper respiratory symptoms
  • Episodes that may be triggered by specific stimuli (cold exposure, vaccines)
  • Family history of autoinflammatory disease or amyloidosis

Two or more signs may suggest an autoinflammatory diesase.



For more information on these disorders, please visit:

Autoinflammatory Alliance

Stop Child Autoinflammatory Diseases

National Organization for Rare Disorders (NORD)


Contact Us

For more information about the clinic, please call Maureen Ghiroli or Sonia Prakash at 858-966-1700, ext. 4214.